Fig. 3 | Scientific Reports

Fig. 3

From: Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells

Fig. 3

Cell type-specific responses in ZIKV-infected brain tumours and NPCs at the DEG level. (A) Venn diagram of the highest-ranked DEGs in each infected cell line at 24 hpi, relative to Mock. Scatter plots of RNA-Seq Log2(Fold Change) for (B) the 41 overlapping brain tumour DEGs and (C) the 51 overlapping NPC DEGs at 24 hpi, relative to Mock. (D) Barplot of significantly enriched KEGG pathways in the highest-ranked brain tumour DEGs at 24 hpi, relative to Mock. The white numbers at the end of each bar denote the number of DEGs identified for the given term. Significance values were corrected for multiple testing using the Benjamini and Hochberg method (padj ≤ 0.05). Abbreviations, differentially expressed gene (DEG), adjusted p-value (padj).

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