Fig. 5 | Scientific Reports

Fig. 5

From: Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells

Fig. 5

ZIKV-infected brain tumour cell secretome. (A) PCA plot of the 49-plex ELISA averaged Net MFI values (N = 3). (B) Differential secretion of cytokines from ZIKV-infected USP7 and USP13 cells at 12, 24 and 48 hpi, relative to Mock samples (Mean ± SEM, N = 3). Significance values were corrected for multiple testing using the Benjamini and Hochberg method (FDR ≤ 0.05). Asterisk symbol denotes level of significance: *padj ≤ 0.05; **padj ≤ 0.01; ***padj ≤ 0.001; ****padj ≤ 0.0001. Abbreviations, Zika virus (ZIKV), USP7 (P7), USP13 (P13), Above Limit of Quantification (> ULOQ), Lower Limit of Quantification (LLOQ), Not Detected (ND), hours post-infection (hpi), Principal Component (PC), Principal Component Analysis (PCA).

Back to article page