Table 4 Receiver operating characteristic (ROC) analysis for salivary growth factors and chemokines.

From: Salivary chemokines and growth factors in patients with ischemic stroke

Biomarker

Area

95% CI

Cut off point

Sensitivity%

95% CI

Specificity%

95% CI

Likelihood ratio

Chemokines

 MCP-1/CCL2

0.6095

0.4370–0.7820

> 0.5531

72.73

51.85– 86.85%

63.64

42.95–80.27%

2

 MIP-1α/CCL3

0.5083

0.3291–0.6875

< 29.00

59.09

38.73–76.74%

59.09

38.73–76.74%

1.444

 MIP-1β/ CCL4

0.6104

0.4401–0.7807

< 62.91

76.19

54.91–89.37%

45.45

26.92–65.34%

1.397

 MCP-3/CCL7

0.8301

0.7042–0.9561

< 13.84

84.21

62.43–94.48%

72.73

51.85–86.85%

3.088

 Eotaxin/CCL11

0.8788

0.7643–0.9933

< 13.07

85.71

65.36–95.02%

81.82

61.48–92.69%

4.714

 CTACK/CCL27

0.8636

0.7514–0.9758

> 24.99

85.71

65.36–95.02%

77.27

56.56–89.88%

3.771

 GRO-α/ CXCL1

0.5455

0.3697–0.7212

< 9.062

61.9

40.88–79.25%

50

30.72–69.28%

1.238

 IL-8/CXCL8

0.7662

0.6159–0.9165

> 1.812

85.71

65.36–95.02%

68.18

47.32–83.64%

2.694

 MIG/CXCL9

0.9236

0.8425–1.000

> 0.7355

95.45

78.20–99.77%

77.27

56.56–89.88%

4.2

 IP-10/CXCL10

0.874

0.7727–0.9753

< 3.474

90.91

72.19–98.38%

68.18

47.32–83.64%

2.857

 SDF-1α//CXCL12

0.5401

0.3480–0.7322

< 48.54

58.82

36.01–78.39%

45.45

26.92–65.34%

1.078

 MIF

0.7521

0.6054–0.8987

> 0.7623

77.27

56.56–89.88%

63.64

42.95–80.27%

2.125

Growth factors

 Basic FGF

1

1.000–1.000

> 20.05

100

85.13–100.0%

95.45

78.20–99.77%

22

 G-CSF

0.9504

0.8824–1.000

> 0.7525

95.45

78.20–99.77%

86.36

66.67–95.25%

7

 HGF

1

1.000–1.000

> 13.62

100

85.13–100.0%

95.45

78.20–99.77%

22

 IL-3/MCGF

0.9952

0.9825–1.000

< 14.86

100

83.18–100.0%

95.45

78.20–99.77%

22

 LIF

0.9978

0.9907–1.000

> 43.85

100

84.54–100.0%

95.45

78.20–99.77%

22

 M-CSF

0.6529

0.4860–0.8198

> 0.1963

77.27

56.56–89.88%

59.09

38.73–76.74%

1.889

 PDGF-BB

0.9351

0.8535–1.000

< 0.3040

90.48

71.09–98.31%

72.73

51.85–86.85%

3.317

 VEGF

0.7299

0.5698–0.8900

> 1.352

70.59

46.87–86.72%

68.18

47.32–83.64%

2.218

  1. MCP-1/CCL2, monocyte chemoattractant protein-1/chemokine ligands 2; MIP-1α/CCL3, macrophage inflammatory protein 1alpha/chemokine ligands 3; MIP-1β/CCL4, macrophage inflammatory protein 1beta/chemokine ligands 4; MCP-3/CCL7, monocyte chemoattractant protein-3/chemokine ligands 7; Eotaxin/CCL11, eotaxin/chemokine ligand 11; CTACK/CCL27, cutaneous T-cell-attracting chemokine/chemokine ligands 27; GRO-α/CXCL1, growth-regulated alpha protein/chemokine (C-X-C motif) ligand 1; IL-8/CXCL8, interleukin 8/chemokine (C-X-C motif) ligand 8; MIG/CXCL9, monokine induced by gamma interferon/chemokine (C-X-C motif) ligand 9; IP-10/CXCL10, interferon gamma-induced protein 10/chemokine (C-X-C motif) ligand 10; SDF-1α/CXCL12, stromal cell-derived factor 1/chemokine (C-X-C motif) ligand 12; MIF, Macrophage migration inhibitory factor; Basic FGF, fibroblast growth factor; G-CSF, granulocyte colony-stimulating factor; HGF, hepatocyte growth factor; IL-3/MCGF, interleukin-3/mast cell growth factor; LIF, leukemia inhibitory factor; M-CSF, macrophage colony-stimulating factor; PDGF-BB, platelet-derived growth factor isoform BB; VEGF, vascular endothelial growth factor.
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