Table 2 Univariate analysis and multivariate analysis of correlation between overall survival and multivariable characteristics in TCGA patients using the Cox proportional hazards regression model.

From: Astragalus mongholicus and Hedyotis diffusa willd inhibit cell proliferation by attenuating the miR-582-3p-p27 signaling pathway in LUAD

Characteristics

Total (N)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age

502

    

<=65

240

Reference

   

> 65

262

1.210 (0.900–1.625)

0.206

  

Female

272

Reference

   

Male

240

1.024 (0.765–1.371)

0.873

  

T stage

509

    

T1&T2

443

Reference

   

T3&T4

66

2.385 (1.634–3.481)

< 0.001

2.251 (1.474–3.438)

< 0.001

N stage

496

    

N0

331

Reference

   

N1

94

2.350 (1.664–3.321)

< 0.001

2.319 (1.555–3.458)

< 0.001

N2

71

3.224 (2.208–4.706)

< 0.001

3.129 (2.043–4.794)

< 0.001

M stage

365

    

M0

342

Reference

   

M1

23

2.330 (1.360–3.991)

0.002

1.607 (0.892–2.894)

0.114

hsa-miR-582-3p

512

    

Low

258

Reference

   

High

254

1.382 (1.030–1.856)

0.031

1.616 (1.142–2.286)

0.007