Fig. 2 | Scientific Reports

Fig. 2

From: Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma

Fig. 2

XN and HOP EX affect HNSCC stemness: (A) Sphere formation assays show how XN and HOP EX affect the ability to form spheroids by UMSCC103 AND CAL33. (B) Histograms represent the decrease in the size of spheres after treatments with XN and HOP EX (*** P≤0,001) (C) Surface stemness markers expression after treatments. (D) qRT PCR of “stemness” genes. XN and HOP EX treatments reduce the expression of all these genes in UMSCC103 (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001). (E) Colony formation assay (images and ImageJ quantification) shows XN an HOP EX affects the clonogenicity ability of UMSCC103 (***P ≤ 0.001, ****P ≤ 0.0001).

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