Table 2 The impact of E. coli infection, E. coli infection treated with ZnO NPs, and ZnO NPs on the hematological parameters in female albino rats (Rattus rattus).

From: Antibacterial impact of biosynthesized zinc oxide nanoparticles on uropathogenic Escherichia coli and in vivo assessment of physiological and histological alterations

Tested

parameter

Group 1

(control)

Group 2

(infected)

Group 3

(infected + ZnO NPs)

Group 4

(ZnO NPs)

Mean ± SD

Mean ± SD

P1

Mean ± SD

P1

P2

Mean ± SD

P1

P2

P3

RBC (× 106/μl)

5.16 ± 0.40

5.82 ± 0.30a

0.02044

5.44 ± 0.37

0.52691

0.28246

5.67 ± 0.32

0.09028

0.88721

0.67975

HGB (g/dL)

12.75 ± 0.47

13.60 ± 0.42a

0.02636

13.12 ± 0.49

0.54891

0.31820

13.26 ± 0.49

0.26482

0.62331

0.94600

HCT (%)

34.1 ± 1.61

37.47 ± 0.80a

0.01490

34.98 ± 2.46

0.81329

0.09326

36.45 ± 1.63

0.11987

0.74153

0.47466

MCV (fL)

66.50 ± 2.06

64.56 ± 2.65

0.57613

64.31 ± 2.44

0.46793

0.99774

65.03 ± 2.45

0.77674

0.98580

0.95190

MCH (Pg)

24.80 ± 1.16

23.45 ± 1.23

0.29090

24.18 ± 1.24

0.83765

0.75569

23.95 ± 1.45

0.66413

0.90485

0.98879

MCHC (g/dl)

37.46 ± 0.69

36.26 ± 1.26

0.58236

37.60 ± 1.94

0.99893

0.49733

36.86 ± 2.14

0.91686

0.91686

0.86017

RDW-CV (%)

12.18 ± 0.18

12.06 ± 0.46

0.94169

12.03 ± 0.38

0.88595

0.99845

11.86 ± 0.34

0.43903

0.76954

0.85119

WBCs (× 103/μl)

5.45 ± 0.87

7.38 ± 1.50

0.37555

9.07 ± 2.36a

0.02683

0.48583

10.37 ± 2.79a

0.00227

0.08136

0.68935

Neutrophils (× 103/μl)

0.344 ± 0.18

0.632 ± 0.42

0.86439

0.802 ± 0.83

0.61309

0.96716

0.105 ± 0.86

0.25765

0.67656

0.90705

Lymphocytes (× 103/μl)

4.58 ± 1.05

6.04 ± 1.72

0.60665

7.38 ± 2.54

0.11083

0.66517

8.34 ± 2.44a

0.02101

0.23404

0.84563

Monocytes (× 103/μl)

0.529 ± 0.09

0.690 ± 0.15

0.44024

0.876 ± 0.19a

0.01814

0.32556

0.970 ± 0.26a

0.00246

0.06877

0.80969

PLT (× 103/μl)

855.8 ± 153.64

480.5 ± 95.76a

0.00034

900.667 ± 100.22b

0.93011

0.00009

927.5 ± 153.78b

0.77157

0.00004

0.98349

MPV (fL)

6.73 ± 0.08

6.81 ± 0.29

0.93814

6.78 ± 0.29

0.98543

0.99553

6.88 ± 0.26

0.73089

0.96686

0.89950

PCT (%)

0.545 ± 0.09

0.388 ± 0.14a

0.00870

0.610 ± 0.07b

0.65530

0.00062

0.635 ± 0.09b

0.40550

0.00023

0.97311

PDW (fL)

11.06 ± 0.26

11.70 ± 1.45

0.59472

11.26 ± 0.64

0.97782

0.82242

11.45 ± 0.64

0.86892

0.95829

0.98274

  1. * Values are expressed as Means ± SD (n = 6). P1 represents significance difference with respect to control group (1). P2 represents significance difference with respect to Infected group (2). P3 represents significance difference with respect to Infected + ZnO NPs group (3). Differences between means were considered significant at P < 0.05. aSignificant to the control group (1), bSignificant to the infected group (2).
Back to article page