Fig. 7 | Scientific Reports

Fig. 7

From: Chronic chlorothalonil exposure inhibits locomotion and interferes with the gut-liver axis in Pelophylax nigromaculatus tadpoles

Fig. 7

Potential mechanisms by which environmental concentrations (10 µg/L) of chlorothalonil treatments cause alterations in the gut-liver axis homeostasis in P. nigromaculatus tadpoles. The main mechanisms included: (1) Exposure to environmental concentrations of chlorothalonil can lead to disturbances in the intestinal microbiota and liver damage, and liver interacts with intestinal microbiota. (2) Gut dysbiosis induced by exposure to environmental concentrations of chlorothalonil mediates amino acid imbalances in the gut, which in turn disrupts glycerophospholipid metabolism in the liver. Dashed arrows indicate possible causes. Red and purple arrows indicate significant increases and significant decreases respectively.

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