Table 3 Stratification by depth of invasion in pT4a patients with gingivobuccal squamous cell carcinoma.
Variables | Shallow (DOI ≤ 10 mm) (n = 72, %) | Deep (DOI > 10 mm and tumor > 40 mm) (n = 44, %) | p value* |
|---|---|---|---|
Age (years, median) | 58 | 55 | 0.27 |
Age subgroup (years) | 0.052 | ||
< 65 | 60 (83.3) | 42 (95.5) | |
≥ 65 | 12 (16.7) | 2 (4.5) | |
Sex | 0.53 | ||
Female | 2 (2.8) | 0 (0) | |
Male | 70 (97.2) | 44 (100) | |
Oral cavity subsite | 0.046* | ||
Bucca, gingiva, lip | 60 (83.3) | 41 (93.2) | |
Retromolar | 9 (12.5) | 0 (0) | |
Overlapping | 3 (4.2) | 3 (6.8) | |
Pathologic nodal status | 0.048* | ||
pN0 | 44 (61.1) | 21 (47.7) | |
pN+ | 22 (30.6) | 23 (52.3) | |
Node excision only | 6 (8.3) | 0 (0) | |
Extra-nodal extension | 0.046* | ||
Yes | 9 (12.5) | 13 (29.5) | |
Resected margin status | 0.30 | ||
Positive | 4 (5.6) | 5 (11.4) | |
Free | 67 (93.1) | 39 (88.6) | |
Perineural invasion | 0.36 | ||
Yes | 20(27.8) | 16 (36.4) | |
No | 51(70.8) | 28 (63.6) | |
Lympho-vascular invasion | 0.71 | ||
Yes | 8 (11.1) | 6 (13.6) | |
No | 63 (87.5) | 38 (83.4) | |
Treatment modality | |||
Adjuvant RT/CCRT | 61 (84.7) | 39 (88.6) | 0.55 |
