Table 2 Differentially expressed genes (DEGs) upregulated in neonates but downregulated in adult mice (Gene set 1).
No. | Gene symbol | Full name | Function |
|---|---|---|---|
1 | Tslp | Thymic stromal lymphopoietin | An epithelial-derived pro-inflammatory cytokine that activates different immune and non-immune cells. It has been shown to be a major regulator of type 2 immune response and atopic disease. |
2 | Lyve1 | Lymphatic vessel endothelial hyaluronan receptor 1 | Lymphatic endothelial markers, associated with macrophages, associated with anti-inflammatory, and possibly associated with the repair microenvironment. |
3 | Mgl2 | Macrophage galactose N-acetyl-galactosamine specific lectin 2 | Expressed in connective tissue macrophages and bone marrow-derived dendritic cells, MGL activation inhibits the immune response by inducing IL-10 secretion from DCs, promoting Treg cell differentiation, and favorably inhibiting T cell activation. |
4 | Cmah | Cytidine monophospho-N-acetylneuraminic acid hydroxylase | Present in porcine sialic acid, the gene is inactivated in the human body. |
5 | Mrc1 | Mannose receptor, C type 1 | Apoptosis associated factors, which have been shown to modulate autophagy, two splice variants of MCL-1 (MCL-1Â L and MCL-1Â S), MCL-1Â L has a pro-apoptotic effect, and MCL-1Â S has an anti-apoptotic effect. |
6 | Ccdc73 | Coiled-coil domain containing 73 | Mouse fertility-related genes, expressed in the testis. |
7 | Ociad2 | OCIA domain containing 2 | Present in embryonic stem cell lines, procancer factors, inhibition of mitochondria-initiated apoptosis. |
8 | Mboat1 | Membrane bound O-acyltransferase domain containing 1 | Ferroptosis inhibitors, which inhibit ferroptosis by remodeling cellular phospholipid precursors. |
9 | Clec4a3 | C-type lectin domain family 4, member a3 | It belongs to the C-type lectin gene, which is widely expressed in fetal precursor macrophages, lost during differentiation into microglia, and has been shown to be associated with neuronal survival in inbred rats. |
10 | Ipcef1 | Interaction protein for cytohesin exchange factors 1 | Its mRNA expression is significantly increased in peripheral nerve injury, which may be the mechanism of neuroinjury-induced changes in DRG membrane receptor trafficking in neuropathic pain conditions. |
11 | Atp1b1 | ATPase, Na+/K + transporting, beta 1 polypeptide | Immune and inflammatory regulators, with antiviral effects, are binding partners for IgLON, a nerve cell adhesion molecule that plays a role in nerve cell adhesion, neurite outgrowth, and synapse formation. |
