Table 3 Gene ontology (GO) enrichment analysis results based on biological processes (Gene sets 2–4).
Description | Gene list |
|---|---|
38 DEGs in Gene set 2 | |
DNA metabolic process | Brca1, Ccne1, Chek1, Hells, Lig1, Mcm3, Mcm2, Mcm4, Mcm5, Uhrf1, Pold1, Pole, Prim1, Rad51ap1, Top2a, Ung, Exo1, Chaf1a, Zgrf1, Dtl, Topbp1, Atad5, Brip1, Clspn, Rad54b |
DNA replication | Brca1, Ccne1, Lig1, Mcm3, Mcm2, Mcm4, Mcm5, Pold1, Pole, Prim1, Chaf1a, Dtl, Topbp1, Atad5 |
Mitotic cell cycle process | Brca1, Ccne1, Ccnf, Chek1, Lig1, Mcm3, Mcm2, Mcm4, Nes, Uhrf1, Pole, Stil, E2f7, Dtl, Prc1, Topbp1, Clspn |
Regulation of mitotic cell cycle phase transition | Adamts1, Brca1, Ccne1, Chek1, RRM2, Stil, E2f7, Dtl, Topbp1, Atad5, Pkmyt1, Clspn |
Homologous recombination | Brca1, Top2a, Topbp1, Brip1, Rad54b |
Base-excision repair | Lig1, Pold1, Pole, Ung |
Negative regulation of gene expression via CpG island methylation | Brca1, Hells, Uhrf1 |
Mitotic cell cycle phase transition | Ccne1, Ccnf, Chek1, Nes, Pole |
Somatic recombination of immunoglobulin genes involved in immune response | Ung, Exo1, Atad5 |
Postreplication repair | Brca1, Pold1, Dtl |
Positive regulation of DNA replication | Jun, E2f7, Atad5 |
Mitotic spindle organization | Uhrf1, Stil, Prc1 |
Negative regulation of organelle organization | Ccnf, Chek1, Mcm2, Top2a |
803 DEGs in Gene set 3 | |
Regulation of cell activation | Acta2, Adora2a, Ahr, Arg2, Bst1, Cd19, Cd24a, Cd38, Cd4, Cd44, Cst7, Ctsc, Cd55, Dpp4, Fas, Fcgr2b, Fgfr1, Fgl2, Fgr, Flot2, Flt3, Flt3l, Pdpn, Lilrb4b, H2-Ab1, Id2, Igf1, Il1b, Itgal, Klrd1, Lgals1, Anxa1, Mmp14, Mmp8, Cd200, Clec4d, Nr4a3, Pparg, Ptpn22, Rara, Rasgrp1, Ccl5, Spn, Cd40, Pglyrp1, Plscr1, Nr1h3, Zap70, Ikzf3, Klrk1, Tnfsf14, Pf4, Stap1, Vav3, Cd274, Lrrk2, Mzb1, Tnfrsf13c, Fcho1, Gimap3, Clec2i, Lmo1, Btla, Nr1d1, Zbtb16, Zc3h12d, Emilin2, Nod2, Vsig4, Sirpb1a, Gm5150, Sirpb1b, Sirpd, Sirpb1c, Ildr2 |
Positive regulation of immune response | Bcl2a1d, Blk, Bmx, C2, C3, C4b, C5ar1, Casp4, Cd19, Ms4a1, Cd24a, Cd36, Cd38, Cd4, Cd44, Cd79a, Bcar1, Cd55, Dpp4, Fcna, Fpr2, Fpr1, Gbp2, H2-Ab1, Cfb, Ifi203, Il1b, Il18r1, Klrd1, Anxa1, Ltf, Nr4a3, Cfp, Ptpn22, Rara, Rasgrp1, Cd40, Plscr1, Nr1h3, Zap70, Sh2d1b1, Klrk1, Clec4n, Stap1, Vav3, Trem3, Cd274, Stmp1, Tnfrsf13c, Fcho1, Usp50, Gimap3, Clec2i, Mapkapk3, Oas1c, Colec12, Tlr8, Skint3, Treml4, Ifi207, Ifi205, Pde4d, Trim30b, Myo1g, Nod2, Nlrc4, Scimp, Cd300ld3, Tnip3, Mndal |
Positive regulation of response to external stimulus | Adora2b, C3, C5ar1, Casp4, Cd24a, Cd36, Cxcr3, Ccr1, Ctsc, Cttn, Dpp4, Fgfr1, Fkbp1b, Fpr2, Gbp2, Cxcl1, Ifi203, Il1b, Klrd1, Lgals1, Ltf, Mmp8, Osm, P2rx4, Pgf, Plat, Ptpn22, Rasgrp1, S100a8, S100a9, Ccl5, Ccl7, Plscr1, Nr1h3, Sh2d1b1, Klrk1, Pla2g7, Tnfsf14, Ccl24, Clec4n, Stap1, Trem3, Lrrk2, Stmp1, Usp50, Gimap3, Mapkapk3, Lgals2, Oas1c, Colec12, Tlr8, Nrg1, Treml4, Ifi207, Ifi205, Trim30b, Emilin2, Nod2, Nlrc4, Scimp, Scarf1, Cd300ld3, Tnip3, Mndal |
Leukocyte migration | Adora1, C5ar1, Cd24a, Cxcr3, Ccr1, Ednrb, Eps8, Cxcl1, Il1b, Itga4, Itgal, Itgb7, Kit, Anxa1, Mmp9, Prtn3, S100a8, S100a9, Ccl5, Ccl7, Ccl8, Cxcl2, Spn, Tnfsf14, Arhgef5, Ccl24, Pf4, Vav3, Trem3, Cxcl16, Itga1, Pde4d, Retnlg, Myo1g, Jaml, Cxcl3, Trim55 |
Negative regulation of immune system process | Acp5, Adora1, Adora2a, Ahr, Arg2, Cd24a, Cd44, Ccr1, Col3a1, Cst7, Cd55, Dpp4, Fas, Fcgr2b, Fgl2, Fgr, Flt3, Lilrb4b, Id2, Ifi203, Igf1, Klrd1, Anxa1, Cd200, Nme2, Pira2, Lilra6, Pirb, Plcb1, Pparg, Ptpn22, Rara, Spn, Pglyrp1, Nr1h3, Ezr, Sh2d1b1, Samhd1, Pf4, Stap1, Cd274, Irak3, Klrb1b, Gimap3, Clec2i, Smpdl3b, Oas1c, Pilrb1, Btla, Nr1d1, Ifi207, Ifi205, Zc3h12d, Nod2, Vsig4, Ildr2, Mndal |
Innate immune response | Arg2, Blk, C2, Ciita, C3, Camk2a, Casp4, Cd2, Cd24a, Camp, Cybb, Cd55, Ear2, Wfdc18, Fcna, Fgr, Gbp2, Gch1, H2-Ab1, Cfb, Klrd1, Anxa1, Ltf, Marco, Gbp4, Clec4d, Padi4, Cfp, S100a8, S100a9, Ccl5, Ccl7, Ccl8, Slpi, Pglyrp1, Zap70, Sh2d1b1, Klrk1, Msrb1, Il36a, Samhd1, Ccl24, Clec4n, Cxcl16, Wfdc21, Ifitm3, Stmp1, Ifitm1, Clec4b1, Kynu, Ifitm7, Stx11, Ifitm2, Smpdl3b, Cdc42ep2, Oas1c, Tlr8, Ifitm6, Treml4, Gsn, Trim30b, Fcgr4, Nod2, Nlrc4, Clec4a1, Wfdc17 |
Leukocyte activation | Adora2b, Ahr, Bcl2a1d, C5ar1, Runx2, Cd19, Cd2, Ms4a1, Cd24a, Cd38, Cd4, Cd44, Cd79a, Clu, Camp, Dnase1l3, Dpp4, Fas, Fcgr2b, Fgl2, Fkbp1b, Flt3, Flt3l, Lilrb4b, H2-Ab1, Cfb, Id2, Igkc, Il18r1, Itgal, Itm2a, Kit, Lepr, Lgals1, Anxa1, Ly6d, Clec4d, Ndrg1, Nfil3, Nr4a3, Pirb, Ptpn22, Rasgrp1, Ccl5, St3gal1, Spn, Stat4, Cd40, Zap70, Ikzf3, Sh2d1b1, Klrk1, Sh2d2a, Batf, Tnfrsf13c, Batf2, Stx11, Gimap3, Wwp1, Pilrb1, Zc3h12d, Gapt, Fcgr4, Jaml, Spib |
Regulation of interleukin-1 production | Acp5, Arg2, Casp4, Cd36, Lilrb4b, Gstp2, Gstp1, Ifi203, Igf1, Ccn1, Il1r2, Anxa1, Serpinb1a, Stmp1, Usp50, Tlr8, Gstp3, Ifi207, Ifi205, Nod2, Nlrc4, Mndal |
Regulation of tumor necrosis factor superfamily cytokine production | Acp5, Arg2, Tspo, Cd2, Cd24a, Cd36, Clu, Cybb, Fcgr2b, Flt3, Lilrb4b, Gstp2, Gstp1, Igf1, Ccn1, Ltf, Mmp8, Ptpn22, Rara, Rasgrp1, Spn, Cd274, Lrrk2, Irak3, Akap12, Oas1c, Cd300ld, Gstp3, Nod2 |
Positive regulation of MAPK cascade | Acta2, Adora1, Bmp2, C3, C5ar1, Cd24a, Cd36, Cd4, Cd44, Chi3l1, Ccr1, Dab2, Dok2, Fcgr2b, Fgf9, Fgfr1, Fpr2, Gcnt2, Hgf, Igf1, Igfbp6, Il1b, Kit, Lepr, Osm, Pde8a, Plcb1, Ptpn22, Rasgrp1, Ccl5, Ccl7, Ccl8, Sorbs3, Cd40, Gdf15, Spry2, Arhgef5, Ccl24, Lrrk2, Avpi1, Akap12, Itga1, Nrg1, Gsn, Trim30b, Nod2, Scimp, Glipr2 |
Regulation of peptidase activity | Bcl2a1d, Cd44, Cst7, Cstb, Ctsk, Wfdc18, Fas, Nr4a1, Ifi203, Ccn1, Ltf, Mmp9, Ngp, Serpinb2, Pparg, S100a8, S100a9, Slpi, Serpinb6a, Serpinb8, Stfa1, Stfa2, Stfa3, Timp1, Perp, Serpinb1a, Aph1c, Pi16, Usp50, Csta2, Cyfip2, Aph1b, Ifi207, Ifi205, Gsn, Cd109, Stfa2l1, Nlrc4, Spink10, Csta3, Cstdc4, Mndal |
Response to molecule of bacterial origin | Ace, Acp5, Ahr, C5ar1, Casp4, Cd24a, Cd36, Ednrb, Fcgr2b, Gbp2, Gch1, Cxcl1, Gstp1, Nr4a1, Il1b, Mmp8, Ptpn22, Rara, S100a8, S100a9, Cxcl2, Slpi, Plscr1, Nr1h3, Klrk1, Il36a, Mgst1, Pf4, Stap1, Cd274, Cxcl16, Wfdc21, Irak3, Mapkapk3, Nr1d1, Pde4d, Fcgr4, Nod2, Cxcl3, Tnip3 |
Positive regulation of apoptotic process | Ace, Adora2a, Ahr, Anxa5, Bcl2a1d, Bmp2, Tspo, Camk2a, Capn2, Casp4, Cd24a, Cd44, Clu, Cxcr3, Ctsc, Ctsk, Fas, G0s2, Gch1, Nr4a1, Ccn1, Il1b, Itga4, Lgals1, Anxa1, Ltb, Mmp9, Sik1, Nr4a3, Osm, Pparg, Rapsn, Rarg, S100a8, S100a9, Ccl5, Cd40, Plscr1, Klrk1, Olfm1, Cd274, Dedd2, Aifm2, Akap12, Trps1, Lgals2, Itga1, Gsn, Zbtb16, Emilin2, Nlrc4 |
Cell-cell adhesion | Alcam, Cd2, Cd24a, Cd44, Emb, Pdpn, Ccn1, Il1b, Itga4, Itgal, Itgb7, Kit, Lgals1, Cd93, Afdn, Cd200, S100a8, S100a9, Ccl5, Serpinb8, Spn, Stfa1, Stfa2, Stfa3, Nt5e, Slc7a11, Pkp3, Perp, Cdhr3, Anxa9, Rap2b, Csta2, Cyfip2, Lgals2, Olr1, Itga1, Nrg1, Stfa2l1, Jaml, Scarf1, Csta3, Cstdc4 |
Endocytosis | Cd24a, Cd36, Cd44, Cttn, Dab2, Ehd1, Fcgr2b, Lilrb4b, Hpse, Itga4, Itgal, Itsn1, Lepr, Anxa1, Marco, Rara, Sorl1, Unc119, Nr1h3, Ezr, Magi2, Tnk2, Rnasek, Cxcl16, Ifitm3, Lrrk2, Rhou, Fcho1, Rhoj, Cd163, Mapkapk3, Cebpe, Colec12, Reps2, Treml4, Gsn, Rhov, Ldlrad3, Myo1g, Fcgr4, Nod2, Timd4, Sirpb1a, Nostrin |
Negative regulation of leukocyte activation | Adora2a, Arg2, Cd24a, Cd44, Cst7, Fas, Fcgr2b, Fgl2, Fgr, Flt3, Lilrb4b, Id2, Anxa1, Cd200, Pparg, Ptpn22, Spn, Pglyrp1, Nr1h3, Pf4, Cd274, Gimap3, Btla, Nr1d1, Zc3h12d, Vsig4, Ildr2 |
Response to type ii interferon | Ciita, Camk2a, Gbp2, Gch1, H2-Ab1, Gbp4, Ccl5, Ccl7, Ccl8, Ccl24, Cxcl16, Ifitm3, Ifitm1, Kynu, Ifitm7, Stx11, Ifitm2, Cdc42ep2, Ifitm6, Gsn |
Negative regulation of viral genome replication | Ifi203, Ltf, Ccl5, Slpi, Plscr1, Ifitm3, Ifitm1, Ifitm7, Ifitm2, Oas1c, Ifitm6, Ifi207, Ifi205, Mndal |
Positive regulation of cell migration | Acp5, Acta2, Adora2b, Bmp2, C5ar1, Ccr1, Col1a1, Bcar1, Dab2, Fgf9, Fgfr1, Fgr, Fpr2, Gcnt2, Pdpn, Hgf, Igf1, Ccn1, Igfbp5, Il1b, Itga4, Kit, Anxa1, Mmp14, Mmp9, Fam89b, Myo5a, Nr4a3, P2rx4, Pgf, S100a11, Ccl5, Ccl7, Sema6b, Spn, Cd40, Spry2, Pla2g7, Tnfsf14, Ccl24, Cd274, Cxcl16, Dock5, Shtn1, Rhoj, Akap12, Pde4d, Glipr2 |
Regulation of neuroinflammatory response | Cst7, Ctsc, Igf1, Mmp8, Cd200, Pparg, Stap1, Lrrk2, Nr1d1, Cd200r4 |
362 DEGs in Gene set 4 | |
DNA metabolic process | Apobec2, Brca2, Ccne2, Cdc7, Fen1, Mcm6, Mcm7, Pold2, Psmc3ip, Rad51, Rpa2, Timeless, Usp10, Nasp, Rif1, Tipin, Ube2t, Aunip, Cenps, Esco2, Dscc1, Helq, Hspa1a, Gtf2h3, Cgas, Rmi2, Iffo1, Dcaf1, Iho1, Zfp827 |
Regulation of double-strand break repair via homologous recombination | Rad51, Rpa2, Timeless, Rif1, Fignl1, Helq, Cgas, Rmi2 |
Regulation of DNA damage checkpoint | Brca2, Rad51, Rpa2, Ppp1r10, Wdr76 |
Positive regulation of mitotic cell cycle | Brca2, Ccnd1, Ccne2, Cdc25a, Cdc7, Pdgfb, Tal1, Ppp1r10, Fbxo5, Rptor |
Regulation of cell cycle phase transition | Acvr1, Brca2, Ccnd1, Ccne2, Cdc25a, Cdc7, Cdk6, Haspin, Rad51, Rbl1, Rpa2, Timeless, Wee1, Ppp1r10, Tipin, Fbxo5, Rptor, Bcl7a, Wdr76 |
Negative regulation of DNA-templated DNA replication | Timeless, Tipin, Fbxo5 |
Meiotic cell cycle process | Brca2, Ccne2, Haspin, Mcm6, Mcm7, Mybl1, Psmc3ip, Rad51, Fignl1, Fbxo5, Cenps, Iho1 |
Negative regulation of catecholamine secretion | Entpd1, Ptger3, Ptgs1, Gabbr1 |
Cell morphogenesis | Cdk5r1, Efna4, Efnb1, Epha2, Ephb3, Srgap2, Elavl4, Il7r, Klf2, Map7, Numb, Pecam1, Sema4b, Tal1, Cdh23, Wee1, Zfpm1, Pacsin1, Whrn, Klf7, Nbeal2, Rtn4rl1, Klk8, Fry, Col27a1 |
Regulation of cell-cell adhesion | Cd1d1, Socs1, Ccr5, Efnb1, Ephb3, H2-Oa, Il6st, Il7r, Lag3, Mbp, Pik3r1, Sox4, Tjp1, Ets1, Zc3h8, Nrarp, Pag1, Cd276, Mex3b |
Maintenance of blood-brain barrier | Mbp, Ptgs1, Slc12a2, Tjp1 |
Telencephalon development | Btg2, Cdk5r1, Ephb3, Srgap2, Adgrg1, Kif21b, Numb, Sall3, Sall1, Dclk2, Atat1, Rtn4rl1, Disc1 |
Cell-cell adhesion | Acvr1, Arvcf, Entpd1, Cdk5r1, Erf, Ajuba, Jup, Pecam1, Selplg, Tjp1, Cdh23, Cd164, Clstn1, Jam2, Mex3b, Lrrc4, Adgrl1 |
Megakaryocyte development | Tal1, Zfpm1, Gp9, Nbeal2 |
Protein phosphorylation | Acvr1, Ccnd1, Cdc7, Cdk5r1, Cdk6, Epha2, Ephb3, Haspin, Pdgfb, Pik3r1, Prkab1, Wee1, Map4k2, Csnk1e, Pbk, Srpk3, Dclk2, Nuak1, Dyrk4, Sik2, Pask, Map3k9 |
Regulation of cellular senescence | Cdk6, Rbl1, Fbxo5, Nuak1, Cgas |
Endothelium development | Acvr1, Rhob, Fzd4, Pdgfb, Pecam1, Tjp1, Col27a1 |
Morphogenesis of a branching epithelium | Acvr1, Eng, Epha2, Pdgfb, Slc12a2, Timeless, Spry1, Sall1, Nrarp, Adamts16 |
Mitral valve morphogenesis | Acvr1, Sox4, Zfpm1 |
Positive regulation of osteoblast differentiation | Acvr1, Il6st, Jund, Fbxo5, Cd276, Tmem119 |
