Table 4 Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis results (Gene sets 2–4).
Description | Gene list |
|---|---|
38 DEGs in Gene set 2 | |
DNA replication | Lig1, Mcm3, Mcm2, Mcm4, Mcm5, Pold1, Pole, Prim1 |
Homologous recombination | Brca1, Pold1, Topbp1, Brip1, Rad54b |
Cell cycle | Ccne1, Chek1, Mcm3, Mcm2, Mcm4, Mcm5, Pkmyt1 |
Base excision repair | Lig1, Pold1, Pole, Ung |
p53 signaling pathway | Ccne1, Chek1, RRM2 |
803 DEGs in Gene set 3 | |
Hematopoietic cell lineage | Cd19, Cd2, Ms4a1, Cd24a, Cd36, Cd38, Cd4, Cd44, Cd7, Csf2ra, Cd55, Flt3, Flt3l, H2-Ab1, Il1b, Il1r2, Itga4, Kit, Itga1 |
TNF signaling pathway | Fas, Cxcl1, Ifi47, Il1b, Il18r1, Mmp14, Mmp9, Ccl5, Cxcl2, Traf1, Mapk13, Creb3l1, Mlkl, Creb3l3, Nod2, Cxcl3 |
Cytokine-cytokine receptor interaction | Bmp2, Cd4, Cxcr3, Ccr1, Csf2ra, Fas, Gdf3, Cxcl1, Il1b, Il1r2, Il18r1, Lepr, Ltb, Osm, Ccl5, Ccl7, Ccl8, Cxcl2, Cd40, Gdf15, Tnfsf14, Il36a, Ccl24, Pf4, Cxcl16, Tnfrsf13c, Cxcl3 |
Complement and coagulation cascades | C2, C3, C4b, C5ar1, Clu, Cd55, F5, Cfb, Serpinb2, Plat, Procr, Thbd, F13a1, Vsig4 |
Osteoclast differentiation | Acp5, Ctsk, Fcgr2b, Il1b, Pira11, Pira2, Lilra6, Pirb, Pparg, Mapk13, Fcgr4, Sirpb1a, Sirpb1b, Sirpd, Sirpb1c |
Pathways in cancer | Bmp2, Camk2a, Ccnd2, Csf2ra, Ednrb, Fas, Fgf9, Fgfr1, Flt3, Flt3l, Gng10, Gstp2, Gstp1, Gsto1, Hgf, Igf1, Kit, Mmp9, Pgf, Pim1, Plcb1, Pparg, Rasgrp2, Rara, Rasgrp1, Stat4, Traf1, Wnt6, Mgst1, Gng11, Calml4, Egln3, Mgst2, Gstp3, Rasgrp4, Zbtb16 |
Malaria | Cd36, Hgf, Il1b, Itgal, Cd40, Klrk1, Gypc, Klrb1b, Hbb-bs |
Primary immunodeficiency | Ciita, Cd19, Cd4, Cd79a, Cd40, Zap70, Tnfrsf13c |
Fluid shear stress and atherosclerosis | Ass1, Gstp2, Gstp1, Gsto1, Il1b, Il1r2, Mmp9, Plat, Thbd, Mapk13, Mgst1, Calml4, Mgst2, Gstp3 |
B cell receptor signaling pathway | Blk, Cd19, Cd79a, Fcgr2b, Pira11, Pira2, Lilra6, Pirb, Vav3, Ifitm1 |
Proteoglycans in cancer | Camk2a, Cd44, Cd63, Col1a1, Col1a2, Cttn, Erbb3, Fas, Fgfr1, Hgf, Hpse, Igf1, Mmp9, Ezr, Wnt6, Mapk13, Vav3 |
Transcriptional misregulation in cancer | Bcl2a1d, Runx2, Ccnd2, Flt3, Id2, Igf1, Il1r2, Itgb7, Mmp9, Nr4a3, Pax5, Plat, Pparg, Rara, Cd40, Traf1, Cebpe, Zbtb16 |
Amoebiasis | Arg2, Col3a1, Col1a1, Col1a2, Cxcl1, Il1b, Il1r2, Plcb1, Cxcl2, Serpinb6a, Cxcl3 |
Staphylococcus aureus infection | C2, C3, C4b, C5ar1, Camp, Fcgr2b, Fpr2, Fpr1, H2-Ab1, Cfb, Itgal, Fcgr4 |
PI3K-Akt signaling pathway | Ccnd2, Cd19, Col1a1, Col1a2, Eif4ebp1, Erbb3, Fgf9, Fgfr1, Flt3, Flt3l, Gng10, Hgf, Nr4a1, Igf1, Itga4, Itgb7, Kit, Osm, Pgf, Creb3l1, Magi2, Gng11, Itga1, Creb3l3 |
Leukocyte transendothelial migration | Bcar1, Cybb, Itga4, Itgal, Afdn, Mmp9, Mylpf, Ezr, Mapk13, Vav3 |
Aldosterone synthesis and secretion | Camk2a, Nr4a1, Nr4a2, Plcb1, Creb3l1, Cacna1f, Calml4, Creb3l3, Atp1a3 |
Tuberculosis | Ciita, C3, Camk2a, Camp, Fcgr2b, H2-Ab1, Il1b, Mapk13, Cd209f, Calml4, Atp6v0d2, Fcgr4, Nod2 |
PPAR signaling pathway | Cd36, Fabp3, Fabp5, Pltp, Pparg, Nr1h3, Angptl4, Olr1 |
362 DEGs in Gene set 4 | |
Cell cycle | Ccnd1, Ccne2, Cdc25a, Cdc7, Cdk6, E2f3, Mcm6, Mcm7, Rbl1, Wee1, Fbxo5, Esco2 |
Fanconi anemia pathway | Brca2, Rad51, Rpa2, Ube2t, Cenps, Rmi2 |
DNA replication | Fen1, Mcm6, Mcm7, Pold2, Rpa2 |
MicroRNAs in cancer | Ccnd1, Ccne2, Cdc25a, Cdk6, Socs1, E2f3, Efna4, Fscn1, Pdgfb, Pik3r1, Sox4, Zeb1, Rptor |
Regulation of lipolysis in adipocytes | Pde3b, Pik3r1, Ptger3, Ptgs1, Mgll |
Axon guidance | Efna4, Efnb1, Epha2, Ephb3, Srgap2, Pik3r1, Sema4b, Lrrc4 |
