Table 7 Top 10 candidate drugs and their target microglia-dependent DEGs.
Drug terms | Target genes |
|---|---|
Troglitazone CTD 00002415 | RRM2; MCM7; ANXA5; RPA2; BRCA1; MMP9; COL1A1; CDK6; CCND1; EXO1; IL1B; CCL5; CHEK1; PBK; MCM3; MCM5; PPARG; CD36; POLE; MCM2 |
Resveratrol CTD 00002483 | MCM7; BRCA1; PIK3R1; BRCA2; CCND1; EXO1; CHEK1; PBK; CD36; NOP56; RRM2; JUP; ATAD5; ANXA5; IGF1; MMP9; COL1A1; ZEB1; CDK6; IL1B; PECAM1; MCM3; MCM5; PPARG; CD44; MCM2 |
Bisphenol A CTD 00000312 | RRM2; MCM7; TSLP; JUP; BRCA1; PIK3R1; IGF1; BRCA2; ATP1B1; MMP9; NT5E; CCND1; IL1B; CHEK1; PBK; MCM3; MCM5; PPARG; CD36; CD44; MCM2 |
Indole-3-carbinol CTD 00000845 | CDK6; CCND1; IL1B; PPARG; BRCA1; BRCA2; MMP9 |
PD 98,059 CTD 00003206 | COL1A1; MCM7; CCND1; ATAD5; IL1B; CCL5; PPARG; BRCA1; IGF1; CCR5; MMP9 |
Genistein CTD 00007324 | RRM2; MCM7; CTBP2; JUP; ATAD5; BRCA1; IGF1; BRCA2; ATP1B1; MMP9; COL1A1; CDK6; CCND1; IL1B; CHEK1; PBK; PPARG; CD44; MCM2 |
Dasatinib CTD 00004330 | RRM2; MCM7; ATAD5; BRCA1; BRCA2; CDK6; CCND1; EXO1; CCL5; KIT; PBK; PPARG; CLSPN |
dexamethasone CTD 00005779 | COL1A1; CD4; CCND1; IL1B; CCL5; PECAM1; CYBB; PPARG; CD36; PIK3R1; IGF1; MMP9 |
Phorbol 12-myristate 13-acetate CTDÂ 00006852 | CD4; ZEB1; CCND1; TSLP; IL1B; CCL5; PBK; CYBB; PPARG; CD36; MMP9; CD44 |
Methaneseleninic acid CTD 00000412 | RRM2; CDK6; MCM7; CCND1; MCM3; RPA2; MCM5; IGF1; BRCA2; CD44; MCM2 |
