Fig. 3 | Scientific Reports

Fig. 3

From: A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL

Fig. 3

(A) Schematic diagram illustrating the experiment in Hnrnpk flox Cd4CreERT2 transgenic mice. D: day, W: week, OXA: oxazolone, 4OHT: 4-hydroxy-tamoxifen. Blood collection was performed 24 h after OXA application. Skin samples were collected at the end of the experiment. (B, C) Overview of the ratio between CD3 + cells and CD19 + cells, and between CD4 + cells and CD8 + cells in peripheral blood throughout the experiment. (D, E) Representative flow cytometry plots and quantitative analysis of CD3 + CD4 + T cells in treated and untreated flanks. P = 0.0159. (F, G) Representative flow cytometry plots and quantitative analysis of CD3 + CD8 + T cells in treated and untreated flanks. P = 0.0111. The data were presented as means ± SDs. Statistical analysis was performed using a pair t-test. Differences were considered statistically significant when P < 0.05 (*p < 0.05).

Back to article page