Table 3 Investigation of DEGs through an ontological standpoint.
GO category | GO ID | Term | P-value | Genes |
|---|---|---|---|---|
Biological process | GO:0,002,842 | Positive regulation of T cell-mediated immune response to tumor cell | 0.000245087 | HLA-DRB3;HLA-DRB1 |
GO:0,002,839 | Positive regulation of immune response to tumor cell | 0.000366432 | HLA-DRB3;HLA-DRB1 | |
GO:0,002,840 | Regulation of T cell-mediated immune response to tumor cell | 0.000366432 | HLA-DRB3;HLA-DRB1 | |
GO:2,000,514 | Regulation Of CD4-positive, Alpha–Beta T Cell Activation | 0.000511333 | HLA-DRB3;HLA-DRB1 | |
GO:2,000,516 | Positive regulation Of CD4-positive, Alpha–Beta T cell activation | 0.001581045 | HLA-DRB3;HLA-DRB1 | |
GO:0,002,399 | MHC class II protein complex assembly | 0.002165765 | HLA-DRB3;HLA-DRB1 | |
GO:0,002,503 | Peptide antigen assembly with MHC class II protein complex | 0.002165765 | HLA-DRB3;HLA-DRB1 | |
GO:0,002,501 | Peptide antigen assembly with MHC protein complex | 0.003594237 | HLA-DRB3;HLA-DRB1 | |
GO:0,002,381 | Immunoglobulin production involved in immunoglobulin mediated immune response | 0.004004046 | HLA-DRB3;HLA-DRB1 | |
GO:0,046,635 | Positive regulation of Alpha–Beta T cell activation | 0.004004046 | HLA-DRB3;HLA-DRB1 | |
Cellular component | GO:0,042,613 | MHC class II protein complex | 0.002490834 | HLA-DRB3;HLA-DRB1 |
GO:0,030,662 | Coated vesicle membrane | 0.002635341 | TEPSIN;HLA-DRB3; HLA-DRB1 | |
GO:0,042,611 | MHC protein complex | 0.004885387 | HLA-DRB3;HLA-DRB1 | |
GO:0,030,134 | COPII-coated ER to golgi transport vesicle | 0.006547998 | TMED3;HLA-DRB3; HLA-DRB1 | |
GO:0,098,553 | Lumenal side of endoplasmic reticulum membrane | 0.008008107 | HLA-DRB3;HLA-DRB1 | |
GO:0,032,588 | Trans-golgi network membrane | 0.013821758 | TEPSIN;HLA-DRB3; HLA-DRB1 | |
GO:0,012,507 | ER to golgi transport vesicle membrane | 0.030955668 | HLA-DRB3;HLA-DRB1 | |
GO:0,030,658 | Transport vesicle membrane | 0.036310368 | HLA-DRB3;HLA-DRB1 | |
GO:0,030,669 | Clathrin-coated endocytic vesicle membrane | 0.045552255 | HLA-DRB3;HLA-DRB1 | |
GO:0,030,666 | Endocytic vesicle membrane | 0.045588079 | HVCN1;HLA-DRB3; HLA-DRB1 | |
Molecular function | GO:0,032,395 | MHC class II receptor activity | 0.000870867 | HLA-DRB3;HLA-DRB1 |
GO:0,023,026 | MHC class II protein complex binding | 0.006889074 | HLA-DRB3;HLA-DRB1 | |
GO:0,042,609 | CD4 receptor binding | 0.034484249 | HLA-DRB1 | |
GO:0,005,388 | P-type calcium transporter activity | 0.039313504 | ATP2B2 |
