Fig. 4
From: Synthesis, characterization, and exosomal corona formation of self-assembled dipeptide nanomaterials
Acquisition of an exosomal corona on NPs is able to reduce nanotoxicity. (A–C) FaDu cells were treated with Fmoc-Lys NMs (C1: 0.5 mg/mL; C2: 1 mg/mL), Fmoc-Lys NMs-Exos (C1: 0.5 mg/mL-0.1 µg/mL; C2: 0.5 mg/mL-0.2 µg/mL), SiNPs (C1: 25 µg/mL; C2: 60 µg/mL), SiNPs-Exos (C1: 25 µg/mL- 0.1 µg/mL; C2: 60 µg/mL- 0.2 µg/mL), or Exo (C: 0.2 µg/mL) in FCS-free medium and cell viability was measured at indicated time points. Column, mean; bars, ±S.D. *p < 0.05, **** p < 0.0001. (D) Concept how formation of an (exosomal) corona can result in reduced nanotoxicity. Created with BioRender.com.
