Fig. 4
From: Icariin inhibits proliferation and migration of VSMCs via LncRNA H19 competitively binding to HuR
lncRNA H19 reduces the expression of cyclin D1 and MMP-9 via regulation of target mRNAs stability. (A) the levels of cyclin D1 mRNA and MMP-9 mRNA were detected by qPCR after lncRNA H19 overexpression or depletion. (B) and (C) The protein levels of cyclin D1 and MMP-9 after lncRNA H19 overexpression or depletion were detected by western blot assay. (D) the levels of cyclin D1 mRNA and MMP-9 mRNA were examined at different times after administration of actinomycin D. *p < 0.05; **p < 0.001; ***p < 0.001. Data are expressed as mean ± SD from three independent experiments.
