Fig. 8 | Scientific Reports

Fig. 8

From: Integrated spatial and single cell transcriptomics identifies PRKDC as a dual prognostic biomarker and therapeutic target in hepatocellular carcinoma

Fig. 8

Analysis of the correlation between the PRKDC and the immune microenvironment. (A) Association between PRKDC expression and immune subtypes in HCC. Patients with higher PRKDC expression are enriched in C3 (inflammatory) and C4 (lymphocyte depleted) immune subtypes. (B) Heatmap showing the correlation between PRKDC and immune-related genes. (C) Correlation between PRKDC expression and immune cell infiltration. (D) Analysis of PRKDC expression and the immune microenvironment in single-cell multi-datasets. The darker the color, the higher the correlation of the PRKDC corresponding to immune cells in this dataset. (E) Bubble diagram summarizing PRKDC involvement in various biological pathways, including immune response and proliferation pathways. Dot size represents fold change, and color intensity represents statistical significance (FDR). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns > 0.05.

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