Table 4 Comparison of community activation in control and ARPKD samples via ssGSEA analysis.

From: Pilot study using a discrete mathematical approach for topological analysis and ssGSEA of gene expression in autosomal recessive polycystic kidney disease

Term

Group

ES_mean

ES_std

NES_mean

NES_std

Community_0

Control

151.67

235.40

0.170

0.264

Community_1

Control

182.25

361.60

0.204

0.405

Community_2

Control

511.60

158.94

0.573

0.178

Community_3

ARPKD

− 283.63

94.42

− 0.293

0.097

Community_4

ARPKD

99.99

150.57

0.103

0.155

Community_5

ARPKD

458.04

68.47

0.473

0.071

  1. Comparison of community activation between control (healthy) and ARPKD patients. For each community, the mean Enrichment Score (ES_mean) and standard deviation (ES_std) indicate the activation level and variability within the gene set, while the mean Normalized Enrichment Score (NES_mean) and standard deviation (NES_std) were adjusted for gene set size to facilitate community comparisons. Positive scores indicate activation, whereas negative scores indicate suppression. Control community structures (Communities 0, 1, 2) are applied to ARPKD samples, and ARPKD community structures (Communities 3, 4, 5) are applied to control samples.
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