Fig. 8 | Scientific Reports

Fig. 8

From: Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Fig. 8

Illustrated graphic depicting the central pathway proposed in this manuscript: abnormal hemodynamic forces acting on the vascular endothelium induce mitochondrial responses, including an increase in ROS production, that stabilizes the redox sensitive transcription factor HIF-1α. Created in BioRender. Boehme, J. (2025) https://BioRender.com/t77h924.

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