Fig. 5
From: ANGPTL4 suppresses progression and improves cisplatin sensitivity in cervical cancer
ANGPTL4 increases cleaved caspase-3 and cleaved-PARP. Caspase-3, PARP, and their cleaved forms were analyzed using western blot in ANGPTL4-overexpressing cells in (a) the absence or (b) presence of cisplatin. These proteins were determined in ANGPTL4-knockdown cells (c) without or (d) with cisplatin treatment (Supplementary Fig.S1) Relative levels of cleaved PARP were normalized to GAPDH. (e) The illustration summarizes the effects of ANGPTL4 on caspase-3 activation and proposes that this activation, evidenced by increased levels of cleaved caspase-3 and cleaved PARP, enhances the sensitivity of cervical cancer cells to cisplatin, leading to reduced viability and increased apoptosis in cisplatin-treated cells. (Created with BioRender.com / Mahidol University). *P < 0.05, **P < 0.01, and ***P < 0.001.
