Fig. 1
From: Pharmacokinetics and the effectiveness of pyrogen-free bioabsorbable wet adhesives
Key design concepts of pyrogen-free bioabsorbable polymer phosphopullulan. (a) Molecular structure of highly water-soluble polysaccharide pullulan and phosphopullulan. (b) A schematic diagram illustrating the relationship between molecular weight and adhesive area, viscosity, and wettability. As the molecular weight increases, both the adhesive area and viscosity increase, whereas wettability decreases. (c) A schematic diagram illustrating the molecular weight of phosphopullulan and its cross-linking by phosphate groups. An increase in cross-linking with phosphate groups results in a higher molecular weight. (d) Applications of phosphopullulan. By adjusting its molecular weight and processing method, it can be fabricated into various forms, including low-molecular-weight liquids, high-molecular-weight viscous liquids, powders, gels, and films.
