Fig. 5
From: Pharmacokinetics and the effectiveness of pyrogen-free bioabsorbable wet adhesives
Applications of phosphopullulan. In situ tissue regeneration of phosphopullulan gels in (a) rat subcutis after 2Â weeks and 4Â weeks. a: blood vessels; c: connective tissues; fm: fibrous membrane; m: macrophages. Osteocompatibility of phosphopullulan gel implanted in bone defects of rabbits after 4 and 9Â weeks (JFRL stain). BM: bone marrow, Ob: osteoblast, Oc: osteoclast, GC: foreign-body giant cell. Examples of sites where pullulan phosphate is used include the cranial sutures in craniosynostosis treatment, cleft alveolus during surgical treatment using cancellous bone grafting, and lumbar spine during treatment of compression fractures.
