Fig. 5 | Scientific Reports

Fig. 5

From: Author Correction: Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft model by cyclic dipeptides identified from Exiguobacterium acetylicum

Fig. 5

Apoptotic protein expression levels in DKPs treated and un-treated HT-29 cells for 24 h. (A–D) Effect of DKPs on the expression of apoptosis-related proteins in the whole-cell lysate of DKP-1: cyclo (l-Pro-l-Leu) (A), DKP-2: cyclo (l-Pro-l-Val) (B), DKP-3: cyclo (l-Pro-l-Phe) (C), and DKP-4: cyclo (l-Pro-l-Tyr) (D) for 24 h. (E–H) Effect of DKPs on the cytochrome-c levels from the mitochondrial and cytosolic fraction of DKP-1: cyclo (l-Pro-l-Leu) (E), DKP-2: cyclo (l-Pro-l-Val) (F), DKP-3: cyclo (l-Pro-l-Phe) (G), and DKP-4: cyclo (l-Pro-l-Tyr) (H). Western blot analysis was performed using antibodies against CytC, Bid, and GADH served as a housing gene. Data were presented as the mean ± SD (n = 3). Data were analyzed by one-way ANOVA with student’s two-tailed t-test. The asterisks *p < 0.05, **p < 0.001, ***p < 0.0001, ****p < 0.0001, indicates a significant difference between the control in response to DKPs treaments. The groupings were cropped from different gels subjected to identical conditions. Full blots were shown in the Supplementary Information, Fig. S4A–H.

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