Fig. 3
(A) Intersection of DEGs, PANoptosis-related genes, and HIRI-related candidate genes identified via WGCNA. (B) Protein-protein network analysis of HIRI-related gene intersections. (C) Gene enrichment analysis of HIRI-related gene intersections. (D) HIRI-related biomarkers identified by the LASSO algorithm. (E) HIRI-related biomarkers identified by the random forest algorithm. (F) HIRI-related biomarkers identified by the SVM-RFE algorithm. (G) HIRI-related biomarkers identified by the Boruta algorithm. (H) Intersection of HIRI-related biomarkers identified by four machine learning methods. (I) Differential expression of six HIRI-related genes between the non-HIRI and HIRI samples from the GEO combined dataset and GSE151648. * P < 0.05, ** P < 0.01, *** P < 0.001. (J) ROC curves of the discrimination ability of six HIRI-related genes for HIRI outcome from the GEO combined dataset and GSE151648.
