Table 4 The linkage between serum ProBDNF and NPZ-6 trajectory groups presented by conditional and joint probabilities from the group-based dual trajectory model.

From: Dual trajectories of serum brain-derived neurotrophic factor and cognitive function in people living with HIV

NPZ-6 trajectory group

Serum proBDNF trajectory group

Low baseline-Slow improvement

Gradual improvement

Late surge

Total

4a Probability of NPZ-6 group conditional on serum proBDNF group

 Gradual Decline

0.28

0.72

0

1

 Gradual Increase

0.23

0.67

0.10

1

4b Probability of Serum proBDNF group conditional on NPZ-6 trajectory group

 Gradual Decline

0.17

0.19

0

 

 Gradual Increase

0.83

0.84

1

 

 Total

1

1

1

 

4c Joint probability of Serum proBDNF and NPZ-6 trajectory groups

 Gradual Decline

0.04

0.11

0

 

 Gradual Increase

0.20

0.58

0.07

 
  1. 4a, Conditional probability of an individual being in a specific NPZ-6 cognitive trajectory given their serum proBDNF trajectory group. 4b, the probability of an individual belonging to a specific serum proBDNF trajectory group given their NPZ-6 cognitive trajectory; 4c, the joint probabilities, combining the two aspects (serum proBDNF trajectory and NPZ-6 cognitive trajectory) to indicate the probability of both occurring together.
  2. proBDNF, Precursor Brain-derived Neurotrophic Factor; NPZ-6, Composite cognitive score derived from individual cognitive tests.
  3. Values in bold represent high conditional and joint probabilities.
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