Fig. 2 | Scientific Reports

Fig. 2

From: Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

Fig. 2

[18F]FDOPA PET imaging. (A) Representative [18F]FDOPA PET images acquired in the same animal from coronal (top) and axial (bottom) orientations. The BQML scale range shows the 95% and the 40% of the maximum signal detected as maximum and minimum values respectively. (B) Patlak plot modelling applied to a representative animal to assess [18F]FDOPA dynamic uptake in left and right striatum. (C) Striatal [18F]FDOPA Ki compared between nTG, LRRK2-G2019S and LRRK2-R1441C genotypes using a One-way ANOVA test followed by pot-hoc comparisons (Tukey HSD). Each dot on the plot represents data from a single rat. * p < 0.05.

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