Fig. 3 | Scientific Reports

Fig. 3

From: Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

Fig. 3

[18F]fallypride PET imaging reveals elevated levels in dorsal striatum of LRRK2-R1441C rats. (A) Representative [18F]fallypride PET images acquired in the same animal from coronal (top) and axial (bottom) orientations. The BQML scale range shows the 95% and the 40% of the maximum signal detected as maximum and minimum values respectively. (B) Logan Reference plot modelling applied to the representative case to assess [18F]fallypride dynamic uptake in left and right striatum (One-way ANOVA and Tukey). (C) Striatal [18F]fallypride DVR compared between nTG, LRRK2-G2019S and LRRK2-R1441C groups. D and E show the same analysis approach described in B and C but segmenting the striatum in dorsal and ventral regions Two-way ANOVA for genotype and region, post-hoc Tukey tests: *p < 0.05; **p < 0.01; ****p < 0.0001.

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