Table 2 [18F]FDOPA and [18F]fallypride PET tracer dynamic uptake.

From: Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

 

[18F]FDOPA Ki (× 10–2 ml/cm3/min)

[18F]fallypride DVR

  

Total striatum

Dorsal

Ventral

nTG

1.31 ± 0.23

15.99 ± 4.05

15.92 ± 3.96§

9.96 ± 1.92

G2019S

1.30 ± 0.19

16.28 ± 3.15

15.97 ± 2.53§

9.73 ± 0.76

R1441C

1.27 ± 0.12

20.93 ± 2.19*

21.21 ± 2.46§§**

10.55 ± 1.16

  1. Average dynamic tracer uptake in the striatum of animals in the 3 groups investigated. [18F]fallypride DVR in dorsal and ventral striatal segmentations is also shown. Data represent mean ± SD. One- or Two-way ANOVA tests followed by post-hoc comparisons (Tukey HSD) were used to compare between genotypes (*p < 0.05; **p < 0.01) and between regions within genotype: §p < 0.01; §§p < 0.001.
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