Table 3 Common and differential targets associated with docetaxel- and paclitaxel-induced liver injury.

From: FAERS based disproportionality analysis and network pharmacology investigation of taxanes associated drug induced liver injury

Common targets

Paclitaxel-specific targets

Docetaxel-specific targets

EGFR, TACR2, CYP3A4, CCKAR, ABCB1, MERTK, EDNRA, CDK1, SIRT2, CDK2, MET, ALK, ROS1, IGF1R, KDR, PIK3CG, PDE5A, PTPA, MAPK14, PIK3CB, KLK3, CNR1, AURKA, CDK4, MAPK8, EPHB4, JAK2, PIK3CD, JAK1, HSP90AA1, PTPN1, ADORA2A, MMP9, MMP2, HSP90AB1

ERBB2, MMP8, PRKCA, CCNE1, HDAC6, MCL1, MMP1, PSMB9, CTSB, ADAM17, PSMB8, TNF, SCARB1, ITGAL, STAT3, CXCR2, NR1I2, ABCB11

MAPK1, INSR, BACE1, SLC29A1, BCL2, F2, F10, ALOX5, CNR2, CHRM2, CCR1, CCR5, NOD2

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