Fig. 5
From: Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia
Inhibition of TOM7 expression attenuated seizures, learning and memory defects. (A,B) Number and cumulative duration of behavorial seizures. (C,D) Seizure number and cumulative seizure duration of EEGs (nonparametric Mann–Whitney U test). (E-G) Representative EEGs and PSD analyses of each group. (H) Target quadrant time (%). (I) Opposite quadrant time (%). (J) Target zone frequency. (K) Latency to platform (two-way ANOVA with Dunnett’s T3 post-hoc test). Control group, n = 11; Hypoxia negative vector group, n = 12; TOM7 intervention group, n = 14. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, Compared with controls (one-way ANOVA); and #P < 0.05, ###P < 0.001; compared with each other (one-way ANOVA with Dunnett’s T3 post-hoc test). EEGs electroencephalograms, PSD power spectrum density, TOM7 translocase outer mitochondrial membrane 7.
