Table 2 Individual effects of serum interleukin-1 beta (sIL-1β) and the Neuroticism of the big five inventory as binary and continuous variables on the probability of 12-week remission.

From: Interactive dynamic modulation of antidepressant treatment response by serum interleukin-1β and Neuroticism at 12 weeks

Exposure

Group

N

No. (%)

OR (95% CI)

Unadjusted

Adjusteda

sIL-1β (binary)

Lower

539

274 (50.8)

Ref

Ref

Higher

547

216 (39.5)

0.63 (0.50–0.80)‡

0.70 (0.54–0.91)†

sIL-1β (increasing)

N/A

1086

N/A

0.78 (0.67–0.91)†

0.81 (0.72–0.96)†

Neuroticism (binary)

Lower

619

297 (48.0)

Reference

Reference

Higher

467

193 (41.3)

0.77 (0.60–0.99)*

0.80 (0.62–1.02)

Neuroticism (increasing)

N/A

1086

N/A

0.80 (0.70–0.92)†

0.84 (0.72–0.98)*

  1. aAdjusted for age, marital status, monthly income, atypical feature, number of depressive episodes, duration of present illness, number of physical disorders, scores on hospital anxiety & depression scale-anxiety subscale and alcohol use disorder identification test, and treatment steps.
  2. *P < 0.05; †P < 0.01; ‡P < 0.001.
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