Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Scientific Reports
  • View all journals
  • Search
  • My Account Login
  • Content Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • RSS feed
  1. nature
  2. scientific reports
  3. articles
  4. article
Curcuma longa debranched starch assisted synthesis of cerium oxide nanoparticles and its antioxidant, anticancer, antimicrobial, and anti-biofilm activities
Download PDF
Download PDF
  • Article
  • Open access
  • Published: 19 January 2026

Curcuma longa debranched starch assisted synthesis of cerium oxide nanoparticles and its antioxidant, anticancer, antimicrobial, and anti-biofilm activities

  • Siva Sankar Sana1 na1,
  • Vijayalaxmi Mishra1 na1,
  • Ramakrishna Vadde2,
  • Mika Sillanpaa3,4,
  • Saleh Alfarraj5,
  • Pham Van Hung6 &
  • …
  • Seong-Cheol Kim1 

Scientific Reports , Article number:  (2026) Cite this article

  • 825 Accesses

  • 4 Altmetric

  • Metrics details

We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Subjects

  • Microbiology
  • Nanoscience and technology

Abstract

Nowadays, there is a growing emphasis on eco-friendly methods for synthesizing metal nanoparticles (NPs), that avoid chemical processes and the production of harmful substances. In this study, we present a novel green approach for preparing cerium oxide nanodots (CeO2NPs) using Curcuma longa debranched starch as a reducing and capping agent via the sol-gel method. The prepared CeO2NPs were characterized using various techniques, including UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), and zeta potential (ζ). An absorption peak of the particles at 315 nm was detected in the UV-Vis spectrum. Spherical CeO2NPs were observed by SEM and TEM with a 2–4 nm NP range. Energy-dispersive X-ray spectroscopy (EDX) analysis showed that the Ce, oxygen and carbon contents were 68.33 wt%, 25.59 wt and 6.07 wt%, respectively. The CeO2NPs exhibited antioxidant activity with an IC50 value of 3.2 ± 0.23 µg/mL, and 3.66 ± 0.18 µg/mL for DPPH and ABTS free radical scavenging assays, respectively. Furthermore, CeO2NPs exhibited antibacterial activity against Corynebacterium diphtheriae, Klebsiella pneumoniae, Salmonella typhi, and Escherichia coli and antibiofilm activity against Corynebacterium diphtheriae and Escherichia coli. The in vitro cytotoxicity of CeO2NPs against HepG2 cells (IC50 of 178 ± 14 µg/mL) was dose-dependent as evaluated using the MTT assay. These results collectively suggest the diverse functions of CeO2NPs, showcasing their potential as antioxidants, anticancer and antibacterial agents, and their usefulness in biomedical applications.

Similar content being viewed by others

Biosynthesis and characterization of copper oxide nanoparticles from Plumbago zeylanica leaf extract for antibacterial and antioxidant activities

Article Open access 20 August 2025

Biofabrication of copper oxide nanoparticles using Dalbergia sisso leaf extract for antibacterial, antibiofilm and antioxidant activities

Article Open access 30 December 2024

Antibacterial activity of green synthesized copper oxide nanoparticles against multidrug-resistant bacteria

Article Open access 23 October 2024

Data availability

All data used were published in this manuscript and can be requested from the corresponding author.

References

  1. Atapakala, S. et al. Honey mediated synthesis of zinc oxide nanoparticles, and evaluation of antimicrobial, antibiofilm activities against multidrug-resistant clinical bacterial isolates. J. Ind. Eng. Chem. 135, 110–121 (2024).

    Google Scholar 

  2. Razieh, H. S., Fatemeh, S. T., Zahra, S. & Majid, D. Photocatalytic activity and anticancer properties of green synthesized ZnO-MgO-Mn2O3 nanocomposite via Ocimum basilicum L. seed extract. Sci. Rep. 14, 29812 (2024).

    Google Scholar 

  3. Netala, V. R., Hou, T., Sana, S. S., Li, H. & Zhang, Z. Rosmarinic acid-rich Perilla frutescens extract-derived silver nanoparticles: A green synthesis approach for multifunctional biomedical applications including antibacterial, antioxidant, and anticancer activities. Molecules 29, 1250 (2024).

    Google Scholar 

  4. Sankar, S. S., Haldhar, R., Parameswaranpillai, J., Chavali, M. & Kim, S. C. Silver nanoparticles-based composite for dye removal: A comprehensive review. Clean. Mater. 6, 100161 (2022).

    Google Scholar 

  5. Mina, S. et al. Facile synthesis of Tl, Pb, and Bi doped CeO2 nanoparticles and the evaluation of their in-vitro cytotoxicity and photocatalytic performance. J. Indian Chem. Soc. 101, 101350 (2024).

    Google Scholar 

  6. Zahra, F. et al. Green synthesis of cerium oxide nanoparticles via Linum usitatissimum seeds extract and assessment of its biological effects. Micro-nano Let. 19, e270003 (2024).

    Google Scholar 

  7. Naidi, S. N., Harunsani, M. H., Tan, A. L. & Khan, M. M. Green-synthesized CeO2 nanoparticles for photocatalytic, antimicrobial, antioxidant and cytotoxicity activities. J. Mater. Chem. B. 9, 5599–5620 (2021).

    Google Scholar 

  8. Hosseini, M. G. & Aboutalebi, K. Improving the anticorrosive performance of epoxy coatings by embedding various percentages of unmodified and imidazole modified CeO2 nanoparticles. Prog Org. Coat. 122, 56–63 (2018).

    Google Scholar 

  9. Nadeem, M. et al. Green synthesis of cerium oxide nanoparticles (CeO2 NPs) and their antimicrobial applications: A review. Int. J. Nanomed. 15, 5951–5961 (2020).

    Google Scholar 

  10. Korkmaz, N. et al. Synthesis of CeO2 nanoparticles from hemp leaf extract: evaluation of antibacterial, anticancer and enzymatic activities. Inorg. Chem. Commun. 159, 111797 (2024).

    Google Scholar 

  11. Janesch, J. et al. Transparent layer-by-layer coatings based on biopolymers and CeO2 to protect wood from UV light. Prog Org. Coat. 138, 105409 (2020).

    Google Scholar 

  12. Chesneau, C. et al. Aerosol-assisted fabrication of mesoporous CeO2 nanoparticles for cargo-controlled delivery application. Surf. Inter. 51, 104682 (2024).

    Google Scholar 

  13. Yandong, B., Yongmei, L., Yuemei, L. & Lijie, T. Advanced biological applications of cerium oxide nanozymes in disease related to oxidative damage. ACS Omega. 9, 8601–8614 (2024).

    Google Scholar 

  14. Wu, Y. & Ta, H. T. Different approaches to synthesizing cerium oxide nanoparticles and their corresponding physical characteristics, and ROS scavenging and anti-inflammatory capabilities. J. Mater. Chem. B. 9, 7291–7301 (2021).

    Google Scholar 

  15. Balaji, S., Mandal, B. K., Vinod Kumar Reddy, L. & Sen, D. Biogenic ceria nanoparticles (CeO2NPs) for effective photocatalytic and cytotoxic activity. Bioengineering 7, 26 (2020).

    Google Scholar 

  16. Ashna, M., Es-Haghi, A., Karimi Noghondar, M., Al Amara, D. & Yazdi, M. E. T. Greener synthesis of cerium oxide nanoemulsion using pollen grains of Brassica napus and evaluation of its antitumor and cytotoxicity properties. Mater. Technol. 37, 525–532 (2022).

    Google Scholar 

  17. Razieh, H. S., Fatemeh, S. T., Zahra, S. & Majid, D. Biosynthesis of ZnO-CeO2-Ag2O nanocomposite with Ocimum basilicum L seed extract as a highly efficient photocatalyst and assessment of their anticancer effects. Chem. Comm. 168, 112955 (2024).

    Google Scholar 

  18. Zahra, S. et al. Biosynthesis of ag doped MgO-NiO-ZnO nanocomposite with Ocimum basilicum L extract and assessment of their biological and photocatalytic applications. J. Mole Stru. 1306, 137895 (2024).

    Google Scholar 

  19. Sabouri, Z. et al. Plant-mediated synthesis of ag and se dual-doped ZnO-CaO-CuO nanocomposite using Nymphaea alba L. extract: assessment of their photocatalytic and biological properties. Biomass Conv Bioref. 14, 32121–32131 (2024).

    Google Scholar 

  20. Andrabi, S. M., Majumder, S., Gupta, K. C. & Kumar, A. Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing. Colloid Surf. B. 195, 111263 (2020).

    Google Scholar 

  21. Ju, X. et al. Poly (acrylic acid)-mediated synthesis of cerium oxide nanoparticles with variable oxidation states and their effect on regulating the intracellular ROS level. J. Mater. Chem. B. 9, 7386–7400 (2021).

    Google Scholar 

  22. Abbasi, N., Homayouni, T. M., Ardalan, T. & mRoumi, S. Cerium oxide nanoparticles-loaded on chitosan for the investigation of anticancer properties. Mater. Technol. 37, 1439–1449 (2022).

    Google Scholar 

  23. Darroudi, M. et al. Food-directed synthesis of cerium oxide nanoparticles and their neurotoxicity effects. Ceram. Int. 40, 7425–7430 (2014).

    Google Scholar 

  24. Ioannou, M. E. et al. Synthesis and characterization of cerium oxide nanoparticles: effect of cerium precursor to gelatin ratio. Appl. Sci. 13, 2676 (2023).

    Google Scholar 

  25. Van Hung, P., Duyen, T. T. M., Phi, N. T. L. & Quynh, T. N. Fabrication and functional properties of curcuma starch nanoparticles as affected by different degree of polymerization of debranched curcuma starch. Starch 74, 2100163 (2022).

    Google Scholar 

  26. Ximenes, V. F. et al. Inhibitory effect of gallic acid and its esters on 2,2’-azobis (2- amidinopropane) hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione in erythrocytes. J. Agric. Food Chem. 58, 5355–5362 (2010).

    Google Scholar 

  27. Floegel, A., Kim, D. O., Chung, S. J., Koo, S. I. & Chun, O. K. Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. J. Food Comp. Anal. 24, 1043–1048 (2011).

    Google Scholar 

  28. Madiwale, G. P., Reddivari, L., Holm, D. G. & Vanamala, J. Storage elevates phenolic content and antioxidant activity but suppresses antiproliferative and pro-apoptotic properties of colored-flesh potatoes against human colon cancer cell lines. J. Agric. Food Chem. 59, 8155–8166 (2011).

    Google Scholar 

  29. Ramakrishna, V., Preeti Gupta, K., OrugantiSetty, H. & Anand Kondapi, K. Neuroprotective effect of emblica officinalis extract against H2O2 induced DNA damage and repair in neuroblastoma cells. J. Homeop Ayurv Med. S1, 002 (2014).

    Google Scholar 

  30. Bauer, A. W., Kirby, W. M., Sherris, J. C. & Turck, M. Antibiotic susceptibility testing by a standardized single disk method. Am. J. Clin. Pathol. 45, 493–496 (1966).

    Google Scholar 

  31. Asfaw, T., Negash, L., Kahsay, A. & Weldu, Y. Antibiotic resistant bacteria from treated and untreated hospital wastewater at Ayder Referral Hospital, Mekelle, North Ethiopia. Adv. Microbiol. 07, 871–886 (2017).

    Google Scholar 

  32. Mohanta, Y. K. et al. Anti-biofilm and antibacterial activities of silver nanoparticles synthesized by the reducing activity of phytoconstituents present in the Indian medicinal plants. Front. Microbiol. 11, 1–15 (2020).

    Google Scholar 

  33. Barapatre, A., Aadil, K. R. & Jha, H. Synergistic antibacterial and antibiofilm activity of silver nanoparticles biosynthesized by lignin-degrading fungus. Bioresour Bioprocess. 3, 8 (2016).

    Google Scholar 

  34. Bianca, C. M. & Delia, R. T. Structural modification of fiber and starch in turmeric residue by chemical and mechanical treatment for production of biodegradable films. Inter J. Bio Macro. 126, 507–516 (2019).

    Google Scholar 

  35. Qiuyi, W. et al. Combination ATR-FTIR with multiple classification algorithms for authentication of the four medicinal plants from Curcuma L. in rhizomes and tuberous roots. Sensors 25, 50 (2025).

    Google Scholar 

  36. Khaoula, H., Hamza, E. A. M., Suresh, G. & Malik, M. Green synthesis of cerium oxide nanoparticles using Portulaca oleracea extract: photocatalytic activities. Inorg. chem. Comm. 162, 112243 (2024).

    Google Scholar 

  37. Veena, G. K., Anisha, S. J., Senthil, P., Leena, K., Gayathri, R. & M. B., & Remediation of mixed dyes and chromium (VI) in textile effluent using chemically synthesized cerium oxide nanoparticle. Desalin. Water Treat. 321, 100909 (2025).

    Google Scholar 

  38. Irshad, M. S. et al. Green synthesis, cytotoxicity, antioxidant and photocatalytic activity of CeO2 nanoparticles mediated via orange peel extract (OPE). Mater. Res. Express. 6, 0950a4 (2019).

    Google Scholar 

  39. Davoodbasha, M. A., Saravanakumar, K., Abdulkader, A. M., Lee, S. Y. & Kim, J. W. Synthesis of biocompatible cellulose-coated nanoceria with pH-dependent antioxidant property. ACS Appl. Bio Mater. 2, 1792–1801 (2019).

    Google Scholar 

  40. Wujcicki, Ł. et al. Cerium (IV) chitosan-based hydrogel composite for efficient adsorptive removal of phosphates(V) from aqueous solutions. Sci. Rep. 13, 13049 (2023).

    Google Scholar 

  41. Hu, J. & Zeng, G. Chitosan grafted with gallic acid and cerium dioxide hybrid nanocomposites as environmentally friendly corrosion inhibitors for mild steel: an experimental and computational study. Int. J. Biol. Macromol. 279, 135074 (2024).

    Google Scholar 

  42. Baranchikov, A. E. et al. Biocompatible ligands modulate nanozyme activity of CeO2 nanoparticles. New J. Chem. 47, 20388–20404 (2023).

    Google Scholar 

  43. Fragou, F., Zindrou, A., Deligiannakis, Y. & Louloudi, M. Engineering of oxygen-deficient nano-CeO2-x with tunable biocidal and antioxidant activity. ACS Appl. Nano Mater. 7, 10552–10564 (2024).

    Google Scholar 

  44. Shlapa, Y. et al. Cerium dioxide nanoparticles synthesized synthesized via precipitation at constant pH: Synthesis, physical-chemical and antioxidant properties. Colloids Surf. B. 220, 112960 (2022).

    Google Scholar 

  45. Kim, S. J. & Chung, B. H. Antioxidant activity of levan coated cerium oxide nanoparticles. Carbohydr. Polym. 150, 400–407 (2016).

    Google Scholar 

  46. Hernández-Castillo, Y. et al. Antioxidant activity of cerium oxide as a function of europium doped content. Ceram. Int. 45, 2303–2308 (2019).

    Google Scholar 

  47. Shahbaz, M. Effect of phytosynthesized selenium and cerium oxide nanoparticles on wheat (Triticum aestivum L.) against stripe rust disease. Molecules 27, 8149 (2022).

    Google Scholar 

  48. Khan, M. et al. Efficacy of green cerium oxide nanoparticles for potential therapeutic applications: circumstantial insight on mechanistic aspects. Nanomaterials 12, 2117 (2022).

    Google Scholar 

  49. Hamidian, K., Saberian, M. R., Miri, A., Sharifi, F. & Sarani, M. Doped and un-doped cerium oxide nanoparticles: Biosynthesis, characterization, and cytotoxic study. Ceram. Int. 47, 13895–13902 (2021).

    Google Scholar 

  50. Abbasi, N., Tabrizi, H., Ardalan, M., Roumi, S. & T. & Cerium oxide nanoparticles-loaded on chitosan for the investigation of anticancer properties. Mater. Technol. 37, 1439–1449 (2022).

    Google Scholar 

  51. Balaji, S., Mandal, B. K., Vinod Kumar, R., Sen, D. & L. & Biogenic ceria nanoparticles (CeO2NPs) for effective photocatalytic and cytotoxic activity. Bioengineering 7, 26 (2020).

    Google Scholar 

  52. Aseyd Nezhad, S., Es-haghi, A. & Tabrizi, M. H. Green synthesis of cerium oxide nanoparticle using Origanum majorana L. leaf extract, its characterization and biological activities. Appl. Organomet. Chem. 34, e5314 (2020).

    Google Scholar 

  53. Javid, H., Hashemy, S. I., Heidari, M. F., Esparham, A. & Gorgani-Firuzjaee, S. The anticancer role of cerium oxide nanoparticles by inducing antioxidant activity in esophageal cancer and cancer stem-like ESCC spheres. Biomed. Res. Int. 2022, 1–11 (2022).

  54. Saranya, J. et al. Cerium oxide/graphene oxide hybrid: synthesis, characterization, and evaluation of anticancer activity in a breast cancer cell line (MCF-7). Biomedicines. 11 (2023).

  55. Dutta, D. Cerium oxide nanoparticles as antioxidant or pro-oxidant agents. ACS Appl. Nano Mater. 5, 1690–1701 (2022).

    Google Scholar 

  56. Radulescu, D. M. et al. Green synthesis of metal and metal oxide nanoparticles: A review of the principles and biomedical applications. Int. J. Mol. Sci. 24, 15397 (2023).

    Google Scholar 

  57. Jeevanandam, J. et al. Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts. Nanoscale 14, 2534–2571 (2022).

    Google Scholar 

  58. Zarei, Z. et al. Salvia sclarea L. mediated green synthesis of gold nanoparticles (AuNPs) and evaluation of their antibacterial, anticandidal, and scolicidal properties. Sci. Rep. 15, 33392 (2025).

    Google Scholar 

  59. Khan, M. et al. Nanowarriors from mentha: unleashing nature’s antimicrobial arsenal with cerium oxide nanoparticles. ACS Omega. 9, 15449–15462 (2024).

    Google Scholar 

  60. Javed, K. et al. Surfactant-free synthesis of melon seed-like CeO2 and Ho@CeO2 nanostructures with enriched oxygen vacancies: characterization and their enhanced antibacterial properties. ACS Omega. 9, 33528–33541 (2024).

    Google Scholar 

  61. Fauzia, K. et al. Antibacterial and sunlight-driven photocatalytic activity of graphene oxide conjugated CeO2 nanoparticles. Sci. Rep. 14, 6606 (2024).

    Google Scholar 

  62. Dar, M. A., Gul, R., Karuppiah, P., Al-Dhabi, N. A. & Alfadda, A. A. Antibacterial activity of cerium oxide nanoparticles against ESKAPE pathogens. Crystals 12(2), 179 (2022).

    Google Scholar 

  63. Chang, S., Shuangli, L., Mingxia, H., Xiaoqing, Z. & Mengmeng, S. Antibacterial mechanism of water-soluble CeO. Nanoflowers its Prod. Des. Antibact. Application Appl. Surf. Sci. 679, 161249 (2025).

    Google Scholar 

  64. Chatzimentor, I. et al. Study of biological behavior and antimicrobial properties of cerium oxide nanoparticles. Pharmaceutics 15(10), 2509 (2023).

    Google Scholar 

  65. Marchianò, V. et al. Preparation and characterization of biodegradable gelatin and starch films embedding cerium oxide nanoparticles stabilized by PLGA micelles for antibiofilm applications. J. Mol. Liq. 398, 124215 (2024).

    Google Scholar 

  66. Zamani, K. et al. Antibacterial effect of cerium oxide nanoparticle against Pseudomonas aeruginosa. BMC Biotechnol. 21, 68 (2021).

    Google Scholar 

  67. Miao, K. et al. Recent progress of modified CeO2-based materials for photocatalytic environmental remediation and antibacterial activity. Environ. Fun Mater. 2, 213–227 (2023).

    Google Scholar 

  68. Lan, S. et al. Modification of antibacterial ZnO nanorods with CeO2 nanoparticles: role of CeO2 in impacting morphology and antibacterial activity. Colloid Int. Sci. Comm. 26, 32–38 (2018).

    Google Scholar 

  69. Muthulakshmi, V., Swetha, S., Sivagaami, S. G. & Amutha, S. Employing nanostructured bio-composite scaffold of pectin mediated cerium oxide for tissue engineering applications. J. Mol. Liq. 413, 25935 (2024).

    Google Scholar 

  70. Vinayagam, R. et al. Peltophorum pterocarpum flower mediated synthesis of silver nanoparticles and its catalytic degradation of acid blue 113 dye. Sci. Rep. 15, 26452 (2025).

    Google Scholar 

  71. Prachi, G. et al. Synthesis of hydroxyapatite nanoparticles using Acacia falcata leaf extract and study of their anti-cancerous activity against cancerous mammalian cell lines. Environ. Res. 214, 113917 (2022).

    Google Scholar 

Download references

Acknowledgements

This research was supported by the Regional Innovation System & Education (RISE) program through the Gyeongbuk RISE center, funded by the Ministry of Education (MOE) and the Gyeongsangbuk-do, Republic of Korea (2025-RISE-15-115).This work was supported by the ongoing Research Funding Program at King Saud University, Riyadh, Saudi Arabia (ORF-2026-7).

Funding

The authors received no funding for this work.

Author information

Author notes

  1. Siva Sankar Sana and Vijayalaxmi Mishra contributed equally to this work.

Authors and Affiliations

  1. School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea

    Siva Sankar Sana, Vijayalaxmi Mishra & Seong-Cheol Kim

  2. Department of Biotechnology & Bioinformatics, Yogi Vemana University, Kadapa, 516005, India

    Ramakrishna Vadde

  3. Institute of Research and Development, Duy Tan University, Da Nang, Vietnam

    Mika Sillanpaa

  4. School of Engineering & Technology, Duy Tan University, Da Nang, Vietnam

    Mika Sillanpaa

  5. Zoology Department, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia

    Saleh Alfarraj

  6. Department of Food Technology, International University, Thu Duc District, Ho Chi Minh City, Vietnam

    Pham Van Hung

Authors
  1. Siva Sankar Sana
    View author publications

    Search author on:PubMed Google Scholar

  2. Vijayalaxmi Mishra
    View author publications

    Search author on:PubMed Google Scholar

  3. Ramakrishna Vadde
    View author publications

    Search author on:PubMed Google Scholar

  4. Mika Sillanpaa
    View author publications

    Search author on:PubMed Google Scholar

  5. Saleh Alfarraj
    View author publications

    Search author on:PubMed Google Scholar

  6. Pham Van Hung
    View author publications

    Search author on:PubMed Google Scholar

  7. Seong-Cheol Kim
    View author publications

    Search author on:PubMed Google Scholar

Contributions

Siva Sankar Sana: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Vijayalaxmi Mishra: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Ramakrishna Vadde: Data analysis, Writing – review & editing. Mika Sillanpaa: Writing – review & editing, Saleh Alfarraj: Writing – review & editing, Funding. Pham Van Hung: Supervision, Visualization, Investigation. Seong-Cheol Kim: Writing – review & editing, Validation, Supervision, Resources, Project administration.

Corresponding authors

Correspondence to Siva Sankar Sana, Saleh Alfarraj, Pham Van Hung or Seong-Cheol Kim.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sana, S.S., Mishra, V., Vadde, R. et al. Curcuma longa debranched starch assisted synthesis of cerium oxide nanoparticles and its antioxidant, anticancer, antimicrobial, and anti-biofilm activities. Sci Rep (2026). https://doi.org/10.1038/s41598-026-35249-3

Download citation

  • Received: 09 April 2025

  • Accepted: 05 January 2026

  • Published: 19 January 2026

  • DOI: https://doi.org/10.1038/s41598-026-35249-3

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Keywords

  • Biomimetic synthesis
  • Cerium oxide nanoparticles
  • Hemocompatibility
  • Antioxidant activity
  • Antibiofilm activity
Download PDF

Advertisement

Explore content

  • Research articles
  • News & Comment
  • Collections
  • Subjects
  • Follow us on Facebook
  • Follow us on Twitter
  • Sign up for alerts
  • RSS feed

About the journal

  • About Scientific Reports
  • Contact
  • Journal policies
  • Guide to referees
  • Calls for Papers
  • Editor's Choice
  • Journal highlights
  • Open Access Fees and Funding

Publish with us

  • For authors
  • Language editing services
  • Open access funding
  • Submit manuscript

Search

Advanced search

Quick links

  • Explore articles by subject
  • Find a job
  • Guide to authors
  • Editorial policies

Scientific Reports (Sci Rep)

ISSN 2045-2322 (online)

nature.com sitemap

About Nature Portfolio

  • About us
  • Press releases
  • Press office
  • Contact us

Discover content

  • Journals A-Z
  • Articles by subject
  • protocols.io
  • Nature Index

Publishing policies

  • Nature portfolio policies
  • Open access

Author & Researcher services

  • Reprints & permissions
  • Research data
  • Language editing
  • Scientific editing
  • Nature Masterclasses
  • Research Solutions

Libraries & institutions

  • Librarian service & tools
  • Librarian portal
  • Open research
  • Recommend to library

Advertising & partnerships

  • Advertising
  • Partnerships & Services
  • Media kits
  • Branded content

Professional development

  • Nature Awards
  • Nature Careers
  • Nature Conferences

Regional websites

  • Nature Africa
  • Nature China
  • Nature India
  • Nature Japan
  • Nature Middle East
  • Privacy Policy
  • Use of cookies
  • Legal notice
  • Accessibility statement
  • Terms & Conditions
  • Your US state privacy rights
Springer Nature

© 2026 Springer Nature Limited

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology