Fig. 10

Effect of nicorandil (150 mg/kg, twice, 2h apart, PO) on immunohistochemical protein expression of MAPKERK1/2 in DRG of CCI rats treated with naloxone (1 mg/kg, twice, 2h apart, I.P). Representative images for immuno-stained sections are also shown. All results were expressed as mean ± SEM (n = 5). Results were analyzed by one-way ANOVA followed by Tukey’s post hoc test. * P < 0.05 VS sham, + P < 0.05 VS CCI-nicorandil.