Fig. 12
Effect of nicorandil (150 mg/kg, twice, 2 h apart, PO) on CCI induced histopathological alterations in longitudinal sections of sciatic nerve (A–E) and transverse section of dorsal root ganglia (F–J) of sham (A, F), CCI (B, G), nicorandil (150 mg/kg, twice, 2 h apart, PO) treated CCI rats (C, H), L-arginine (500 mg/kg, I.P) pretreated CCI rats (D, I) and sildenafil (2.5 mg/kg, twice, I.P) pretreated CCI rats (E, J), respectively. All images were captured under magnification power X400 (scale bar: 50 µm) (n = 5). Sciatic nerve: Normal nerve fibers (black arrow), myelin sheath degeneration (yellow arrow), areas of edema (red arrow), Schwann cells nuclei (arrow heads), mononuclear cells infiltration (blue arrow), increase the capillary size (*). Dorsal root ganglia: Normal nerve cells (black arrow), Nissl body in the cytoplasm of nerve cells (Nb), Satellite cells (blue arrow), Nucleus with prominent nucleolus (green arrow), Degenerated neurons with absence of Nissl bodies (yellow arrow), Areas of edema (red arrow), Hypertrophy of satellite cells (arrow heads), The neuronal cells showed loss of the nuclei and showed a ghost cell-like morphology (orange arrow).
