Fig. 13 | Scientific Reports

Fig. 13

From: Nicorandil ameliorates neuropathic and inflammatory pain via TNF-α, IL6/MAPKERK1/2 and NO/cGMP signaling

Fig. 13

Proposed mechanism of nicorandil in relieving neuropathic pain. TRPV1, transient receptor potential vanilloid 1; MOR, µ opioid receptor; NO, nitric oxide; cGMP; cyclic guanosine monophosphate; TNF-α, tumor necrosis factor alpha; IL-6, interleukin 6; MAPKERK1/2; mitogen activated protein kinase (extracellular signal-regulated kinase 1/2); COX2, Cyclooxygenase2.

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