Fig. 2 | Scientific Reports

Fig. 2

From: Nicorandil ameliorates neuropathic and inflammatory pain via TNF-α, IL6/MAPKERK1/2 and NO/cGMP signaling

Fig. 2

Effect of nicorandil (150 mg/kg, twice, 2 h apart, PO) on locomotor activity. Total distance travelled (A), Number of line crossing (B), average speed (C), number of entries in central zone (D), time spent in central zone (E), grooming time (F), number of entries in peripheral zone (G), time spent in peripheral zone (H) and number of rearing (I) assessed by open field test was evaluated 7 h after first dose of nicorandil. All results were expressed as mean ± SEM (n = 4–5). Results were analyzed by unpaired t-test.

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