Fig. 7
Effect of nicorandil (150 mg/kg, twice, 2 h apart, PO) on number of flinches of 1st, 2nd phases (A, B), number of flinches over 1 h (C) and total area under the curve for flinches (D) induced by formalin (50 µl, 1%) in presence of L-arginine (500 mg/kg, I.P, 30 min before first dose of nicorandil), L-NAME (10 mg/kg, I.P, 30 min before each dose of nicorandil), methylene blue (10 mg/kg, I.P, 30 min before first dose of nicorandil), sildenafil (2.5 mg/kg, I.P, 30 min before each dose of nicorandil) and glibenclamide (5 mg/kg, I.P, 30 min before first dose of nicorandil). All results were expressed as mean ± SEM (n = 5–8). Results were analyzed by one-way ANOVA followed by Tukey’s post hoc test *P < 0.05 VS formalin, + P < 0.05 VS nicorandil.
