Fig. 8 | Scientific Reports

Fig. 8

From: Nicorandil ameliorates neuropathic and inflammatory pain via TNF-α, IL6/MAPKERK1/2 and NO/cGMP signaling

Fig. 8

Effect of nicorandil (150 mg/kg, twice, 2 h apart, PO) in absence and presence of naloxone (1 mg/kg, twice, 2h apart, I.P) on malondialdehyde (MDA) (A) and cyclooxygenase 2 (COX-2) (B) serum levels in CCI rats. All results were expressed as mean ± SEM (n = 5). Results were analyzed by one-way ANOVA followed by Tukey’s post-hoc test. * P < 0.05 VS sham, + P < 0.05 VS CCI, # P < 0.05 VS CCI-nicorandil.

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