Table 1 Characteristic craniofacial anomalies observed at 12 + 24 weeks.

From: Variability, asymmetry and sexual dimorphism in craniofacial anomalies in Loeys-Dietz syndrome 2: geometric morphometric analysis in mice

Craniofacial Anomalies

WT males

(%, N = 12)

Het males

(%, N = 9)

WT females

(%, N = 13)

Het females

(%, N = 13)

Fisher’s exact test

(Het vs WT)

Cranial doming

0

44

0

77

p < 0.0001

Nasale asymmetry*

8

67

16

85

p < 0.0001

Upturned nasale

16

44

0

46

P = 0.0060

Sharp P-curve

0

66

7

69

p < 0.0001

Sharp coronoid process

0

60

0

44

p < 0.0001

Hyperplastic condyle

0

100

0

100

p < 0.0001

Localized suture fusions

8

22

0

38

p = 0.0180

Broad suture fusions

16

78

8

69

p < 0.0001

Palate fusion

16

100

0

100

p < 0.0001

  1. Note: WT = Tgfbr2+/+ mice; Het = Tgfbr2G357W/+; P-curve = posterior curve of the zygomatic process of the temporal bone.
  2. *Nasale asymmetry includes mild (commonly seen in wild-type mice) and severe (only seen in Hets). See Supplementary Table 2 for distinction mild/severe and for sex differences.
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