Table 2 Enzyme inhibitor activities of the 1,3,4-oxadiazole derivatives expressed as % of inhibition.
Compounds | LOX Inhibition (%) at 0.25 mM | α-Glucosidase Inhibition (%) at 0.5 Mm | Urease Inhibition (%) at 0.25 mM |
|---|---|---|---|
7a | 92.2 ± 0.5 | 89.42 ± 1.33 | 92.35 ± 1.65 |
7b | 85.3 ± 0.3 | 67.35 ± 1.21 | 51.26 ± 1.39 |
7c | 47.5 ± 0.8 | 45.42 ± 1.59 | 75.35 ± 1.52 |
7d | 82.4 ± 0.6 | 72.35 ± 1.45 | 76.28 ± 1.43 |
7e | 75.4 ± 0.6 | 66.38 ± 1.72 | 62.41 ± 1.57 |
7f | 78.4 ± 0.7 | 78.79 ± 1.29 | 58.26 ± 1.45 |
7g | 53.2 ± 0.4 | 67.54 ± 1.67 | 68.72 ± 1.58 |
7h | 94.5 ± 0.6 | 62.35 ± 1.79 | 53.26 ± 1.35 |
7i | 45.3 ± 0.6 | 84.87 ± 1.53 | 72.54 ± 1.45 |
7j | 85.4 ± 0.7 | 63.25 ± 1.34 | 77.63 ± 1.23 |
7k | 62.1 ± 0.6 | 56.49 ± 1.64 | 86.42 ± 1.55 |
7l | 75.2 ± 0.4 | 75.67 ± 1.62 | 98.45 ± 1.69 |
7m | 35.6 ± 0.7 | 63.84 ± 1.27 | 72.16 ± 1.45 |
7n | 92.8 ± 0.8 | 89.54 ± 1.48 | 87.12 ± 1.76 |
7o | 37.5 ± 0.4 | 52.65 ± 1.78 | 73.52 ± 1.63 |
Quercetin | 89.2 ± 0.6 | - | - |
Acarbose | - | 65.73 ± 1.93 | - |
Thiourea | - | - | 98.21 ± 0.78 |
