Table 3 IC50 values of the 1,3,4-oxadiazole analogues studied for LOX, urease and α-Glucosidase potential.

From: Structural and computational supported development of 2,5-disubstituted-1,3,4-oxadiazole analogues as active LOX, urease, and α-glucosidase inhibitors

Compound

IC50 (µM)

LOX

α-Glucosidase

Urease

7a

3 ± 0.24

7.15 ± 1.34

26.64 ± 1.32

7b

4 ± 1.05

36.54 ± 1.13

123.15 ± 1.24

7c

28.01 ± 0.03

92.08 ± 1.14

38.06 ± 1.28

7d

5 ± 0.05

17.21 ± 1.35

36.09 ± 1.35

7e

42.5 ± 0.3

37.18 ± 1.24

98.16 ± 1.72

7f

8.2 ± 0.4

14.26 ± 1.07

108.50 ± 1.07

7g

26 ± 1.16

36.21 ± 1.04

40.41 ± 1.36

7h

1.0 ± 0.3

39.56 ± 1.37

120.14 ± 1.43

7i

30 ± 1.02

9.12 ± 1.17

39.05 ± 1.31

7j

3.3 ± 0.3

38.01 ± 1.25

33.09 ± 1.02

7k

1.02 ± 0.04

45.56 ± 1.36

28.12 ± 1.04

7l

16 ± 0.01

14.31 ± 1.19

21.85 ± 1.43

7m

105 ± 0.05

38.05 ± 1.26

39.03 ± 1.78

7n

1.5 ± 0.5

7.03 ± 1.08

29.25 ± 1.52

7o

103.26 ± 1.09

86.16 ± 1.18

39.42 ± 1.43

Quercetin

2.3 ± 0.3

-

-

Acarbose

-

37.58 ± 1.76

-

Thiourea

-

 

21.25 ± 0.35