Abstract
Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality worldwide. This study aims to investigate the relationship between the 10-year ASCVD risk score and mental disorders.This study analyzed data from 1154 participants aged 25 to 70 enrolled in the Shiraz Heart Study cohort between 2016 and 2019. The ten-year ASCVD risk score was estimated using the ASCVD risk score estimator recommended by the American College of Cardiology and American Heart Association guidelines. Mental health was evaluated using a 28-item general health questionnaire concurrently with the ASCVD risk calculation. A multiple logistic regression model was employed for multivariate analysis. The mean age of participants was 44.25 ± 8.88 years, and most were men (n = 621, 53.8%). A multiple logistic regression model demonstrated that having ASCVD is associated with increased odds of somatic symptoms (OR 1.138, 95% CI 1.069–1.212), anxiety and insomnia (OR 1.113, 95% CI 1.043–1.188), severe depression (OR 1.173, 95% CI 1.084–1.269), and total general health scores (OR 1.053, CI 1.027–1.079). Another multiple logistic regression model showed that among participants without ASCVD, 10-year ASCVD risk score ≥ 5% is associated with increased odds of somatic symptoms (OR 1.126 95%CI 1.035–1.224), anxiety and insomnia (OR 1.117, 95% CI 1.031–1.211), social dysfunction (OR 1.121, 95% CI 1.034–1.215), severe depression (OR 1.195, 95% CI 1.078–1.324), and total general health scores (OR 1.068, CI 1.035–1.102). ASCVD and a 10-year ASCVD risk score ≥ 5 are associated with the development of mental disorders.
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M.J.Z., J.M., and F.B.F. conceived the idea for the manuscript. M.J.Z., J.M., F.B.F., N.P., I.R.J., S.S.M. and F.Z. collected data. M.S. and M.R. contributed to data analysis and data interpretation. M.R., A.B., H.B.D., and M.B. drafted the manuscript. H.B.D., S.M.S.I., and R.A. revised the manuscript critically. H.B.D. stood as the Guarantor of the manuscript. All authors read and approved the final version of the manuscript. All authors confirm that all methods were carried out in accordance with relevant guidelines and regulations.
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This study was approved by the Ethics Committee of Shiraz University (IR.US.PSYEDU.REC.1403.001), and written informed consent was obtained from the subjects. All methods were carried out in accordance with relevant guidelines and regulations.
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Zibaeenezhad, M.J., Molazadeh, J., Sayadi, M. et al. The effects of atherosclerotic cardiovascular disease and ten-year atherosclerotic cardiovascular disease risk score on mental health status. Sci Rep (2026). https://doi.org/10.1038/s41598-026-35737-6
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DOI: https://doi.org/10.1038/s41598-026-35737-6
