Table 2 Blood biochemical, inflammatory and immunological variables between SLE and MI groups from METAINFLAMMATION cohort.
Hospital reference values | Metabolic syndrome (MS) (n = 85) | Lupus erythematosus systemic (SLE) (n = 66) | P value | |
|---|---|---|---|---|
General biochemistry | ||||
Glucose (mg/dL) | 60–100 | 102 (15) | 91 (13) | < 0.001 |
Glycated hemoglobin (%) | 4.5–6.4 | 5.7 (0.6) | 5.4 (0.4) | 0.001 |
Insulin (µU/mL) | 2–29.1 | 11.9 (0.9) | 9.5 (7.1) | 0.06 |
HOMA-IR | < 2.5 | 2.9 (0.2) | 2.3 (0.2) | 0.15 |
Total cholesterol (mg/dL) | 150.0–200.0 | 185 (33) | 180 (33) | 0.43 |
HDL-cholesterol (mg/dL) | 50.0–90.0 | 52 (16) | 58 (15) | 0.02 |
Triglycerides (mg/dL) | 30.0–200.0 | 128 (48) | 103 (59) | 0.006 |
GOT (U/L) | 6.0–40.0 | 23.7 (6.2) | 23.7 (9.1) | 0.99 |
GPT (U/L) | 6.0–40.0 | 29.6 (10.7) | 22.3 (12.2) | < 0.001 |
GGT (U/L) | 33.5 (27.4) | 21.4 (15.5) | 0.002 | |
Uric acid (mg/dL) | 2.5–6.0 | 5.7 (1.4) | 4.6 (1.2) | < 0.001 |
Inflammatory variables | ||||
LDH (U/L) | 120.0–246.0 | 185.7 (32.2) | 188.2 (36.9) | 0.65 |
PCR (mg/L) | 0.1–10.0 | 3.7 (3.9) | 5.5 (8.8) | 0.11 |
IL-6 (pg/mL) | 0.0–4.4 | 2.2 (2.1) | 3.2 (3.6) | 0.04 |
Ferritin (ng/mL) | 5.0–204.0 | 151.2 (116.2) | 86.3 (74.7) | 0.002 |
Fibrinogen (mg/dL) | 200.0–400.0 | 365.3 (86.1) | 370.9 (124.6) | 0.62 |
D-dimer (ng/mL) | 0.0–500.0 | 358.9 (197.3) | 353.0 (199.4) | 0.68 |
Neutrophils/lymphocyte ratio | 0.78 – 3.5 | 1.8 (0.7) | 2.5 (0.9) | 0.03 |
Hematological variables | ||||
Leukocytes (× 103/µL) | 4.0–11.5 | 6.4 (1.6) | 5.8 (2.4) | 0.02 |
Neutrophils (%) | 1.5–7.5 | 3.9 (1.1) | 3.6 (2.0) | 0.04 |
Lymphocytes (%) | 1.2–4.0 | 2.1 (0.6) | 1.4 (0.5) | 0.37 |
Platelets (× 103/µL) | 150.0–400.0 | 234.3 (48.4) | 230.8 (61.6) | 0.06 |
Hematocrit (%) | 37.0–47.0 | 45.5 (3.7) | 42.7 (2.9) | < 0.001 |
Mean Corpuscular Volume (fL) | 90.7 (7.5) | 91.8 (4.1) | < 0.001 | |
ESR (mm/h) | 9.8 (8.1) | 16.5 (16.2) | 0.04 |
