Fig. 2 | Scientific Reports

Fig. 2

From: Putative long range mossy fiber sprouting and regional cytochrome c oxidase alteration in the hippocampus of patients with mesial temporal lobe epilepsy

Fig. 2

Assessment of neuronal loss in resected hippocampi relative to control with sortilin immunohistochemistry. Shown are microscopical images from five resected hippocampi from patients with mesial temporal lobe epilepsy (MTLE) (A-E) and a postmortem brain as control (CTL) (F). Loss of the labeled neurons is seen in the hilus (Hi), CA3 and CA1 (A, B, C, D) and also in the subiculum (Sub) with variability between samples (B, C). Panel (C1) shows a few remaining pyramidal neurons in the striatum pyramidale (s.p.) of CA1. The pyramidal neurons in CA2 in the resected hippocampus are misaligned and separated from each other, and had fewer and shortened dendrites, in comparison with their counterpart in the control section (D1, F1). Dislocation of granule cells and loss of hilar mossy cells are clearly seen in the sclerotic (D2) as compared to the control (F2) hippocampus. Panels (E, E1) show cell counting in grided zones in the hippocampal subregions. Additional abbreviations: GCL: granule cell layer; s.o.: stratum oriens; s.r.: stratum radiatum. Scale bars are as indicated.

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