Table 3 Univariate analysis of Cox regression for 5-year OS and DSS.

From: Image segmentation-based analysis reveals correlation between IL-1RA overexpression and worse survival outcomes in oral squamous cell carcinoma

Variable

5-year OS

5-year DSS

HR (95% CI)

p

HR (95% CI)

p

Age (years)

≤ 64

Ref

 

Ref

 

> 64

1.151(0.531–2.531–494.531)

0.721

1.183 (0.510–2.745.510.745)

0.695

Tumor grade

WD

Ref

 

Ref

 

MD

0.614 (0.278–1.355.278.355)

0.227

0.680 (0.290–1.596.290.596)

0.376

Tumor budding

no

Ref

 

Ref

 

yes

1.257 (0.504–3.134.504.134)

0.624

1.283 (0.473–3.485.473.485)

0.624

PNI

no

Ref

 

Ref

 

yes

2.163 (0.939–4.982.939.982)

0.070

2.027 (0.825–4.981.825.981)

0.123

Margin status

Compromised

Ref

 

Ref

 

Free

0.511 (0.174–1.499.174.499)

0.221

0.573 (0.167–1.962.167.962)

0.375

T

T1-T2

Ref

 

Ref

 

T3-T4

1.791 (0.820–3.908.820.908)

0.44

2.748 (1.118–6.758)

0.028

N

no

Ref

 

Ref

 

yes

2.780 (1.255–6.157)

0.012

2.998 (1.250–7.192)

0.014

TNM stage

I-II

Ref

 

Ref

 

III-IV

2.807 (1.122–7.023)

0.027

3.683 (1.240–10.938.240.938)

0.019

Locoregional recurrence

no

Ref

 

Ref

 

Yes

2.930 (1.268–6.774)

0.012

3.462 (1.346–8.901)

0.006

IL-1RA expression

Low

Ref

 

Ref

 

High

2.844 (1.134–7.132)

0.026

2.906 (1.063–7.946)

0.038

IL-1R1 expression

Low

Ref

 

Ref

 

High

0.916 (0.415 − 2.020)

0.827

0.846 (0.355–2.021.355.021)

0.707

IL-1ɑ expression

Low

Ref

 

Ref

 

High

1.297 (0.561–3.002.561.002)

0.543

1.330 (0.543–3.258.543.258)

0.533

IL-1ß expression

Low

Ref

 

Ref

 

High

1.494 (0.676 − 3.300)

0.321

1.126 (0.485–2.614.485.614)

0.782

  1. OS, overall survival; DSS, disease-specific survival; HR, hazard ratio; CI, confidence interval; Ref, reference; WD, well differentiated; MD, moderately differentiated; PNI, perineural invasion; T, tumor size/stage; N, lymph node involvement; TNM, tumor-node-metastasis.
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