Fig. 4
From: A repurposing Dapagliflozin via polymeric nanogels for colorectal cancer therapy
In vitro release profile of Dapagliflozin (DAPA) from various formulations: free DAPA, DAPA-loaded nanoparticles (DAPA-PVA-SA-NPs), and three sediment-forming gel formulations (F1, F2, F3). The release study was conducted under simulated gastrointestinal conditions, starting with 0.1N HCl (pH 1.2) for 2 h (h) followed by phosphate buffer (pH 6.8) for the remaining duration. DAPA-PVA-SA-NPs exhibited a sustained and biphasic release pattern, with F2 showing the most controlled release behaviour among the gel formulations. The data demonstrates the potential of the nanoparticulate and gravity-induced hydrogel mass to enhance and modulate DAPA release [Data are presented as mean ± SD. Each data point represents the mean of three independent replicates (n = 3). Statistical analysis was performed using GraphPad Prism v9.0. P-values and 95% confidence intervals were calculated using one-way ANOVA with Bonferroni correction. Assumptions of normality and variance homogeneity were confirmed prior to analysis].
