Fig. 3
From: Role of MNX1-mediated histone modifications and PBX gene family in MNX1-induced leukemogenesis
Alterations in histone methylation are associated with leukemia development. (a & c) Principal component analysis scatter plot of normalized median of ratios using Diffbind and DESeq2 showing variations between the samples in (a) H3K4me3 differential enrichment and (c) H3K4me1 differential enrichment. (b & d) Volcano plot depicting the differential enrichment of H3K4me3 (b), or H3K4me1 (d) between MNX1-vector transduced FL cells (blue) and empty vector transduced FL cells (Ctrl-grey; left panel) or mice leukemia BM cells (red) and empty vector transduced FL cells (right panel).
