Fig. 10

DEIX treatment alone improves bone metabolism and anti-inflammation-related biological processes in hPDLCs . (A) The heatmap exhibiting the expression values of DEIX-specific DEGs in log₁₀ (FPKM + 1) units at the levels of fold change ≥ 2 and p value ≤ 0.05, along with the comparison with those of the control hPDLCs, in which 40 upregulated DEGs (red) and 25 downregulated DEGs are shown. (B) The plot summary of functional enrichment and pathway analysis of significantly enriched modules derived from the DEGs of DEIX-treated hPDLCs in -10 log adjusted p value. Significantly enriched top 10 terms of (C) GO-BP, (D) GO-CC, and (E) GO-MF in the DEIX-derived DEGs are shown. (F and G) The graphs show the significant differences of the indicated DEGs among the cells untreated or exposed to LPS, DEIX, or both at p < 0.05 (n = 3). The letters in panels F and G indicate significant differences among these cells, as shown by a non-parametric ANOVA test followed by Dunn’s multiple comparisons test.