Fig. 2 | Scientific Reports

Fig. 2

From: Therapeutic potency and the related mechanism of deinoxanthin in experimental animal and cell models of periodontitis

Fig. 2The alternative text for this image may have been generated using AI.

Supplementation with DEIX inhibits osteoclastic activation in the inflamed periodontium of rat groups.

(A) TRAP staining images showing the ligature-mediated osteoclast formation and its suppression by DEIX (Bar = 100 μm), in which the tetragonal regions in the upper panels were 4-fold magnified. (B) The TRAP-positive area (%) in the magnified area of rat groups (n = 4). (C) IF assay images indicating the expression levels of RANKL (green) and cathepsin K (red) in the inflamed periodontium of rat groups (Bar = 50 μm). The intensities (a.u.) of (D) RANKL- and (E) cathepsin K-specific immunofluorescences were determined using the ImageJ program (n = 4). *p < 0.05 by unpaired non-parametric test (Kolmogorov-Smirnov test). ns, not significant.

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