Abstract
Atherosclerotic coronary artery disease (CAD) remains a leading cause of death globally, and individual susceptibility is not fully explained by standard risk factors. The role of plasma fatty acid profiles in relation to imaging-defined CAD burden remains less well established. We performed a cross-sectional cohort analysis of 1,002 participants undergoing coronary computed tomographic angiography (CCTA), with blood samples collected immediately prior to contrast administration. Plasma fatty acids were quantified as a percentage of total plasma fatty acids and evaluated for associations with CAD burden, including coronary artery calcium score (CACS), CACS percentile, Gensini score, soft plaque score, and atrial fibrillation (AF). Associations were assessed using multivariate logistic regression, adjusting for age, sex, and cardiovascular risk factors. Higher plasma omega-6 levels were inversely associated with CACS (CAC+; odds ratio [OR] = 0.93, 95% confidence interval [CI] = 0.90–0.97) with similar inverse associations observed for Gensini and soft plaque scores. In contrast, monounsaturated (CAC + OR = 1.09, 95% CI = 1.03–1.15) and saturated fatty acids (CAC + OR = 1.08, 95% CI = 1.04–1.12) were positively associated with CAD burden. No consistent associations were observed with self-reported atrial fibrillation after multivariable adjustment. Plasma omega-6 fatty acids demonstrated inverse associations with imaging-defined CAD burden, suggesting a potential protective role that warrants investigation in longitudinal studies. Saturated and monounsaturated fatty acids were positively associated with CAD, aligning with prior evidence of their atherogenic potential.
Data availability
The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.
Abbreviations
- AF:
-
Atrial fibrillation
- ASCEND:
-
A study of cardiovascular events in diabetes
- BMI:
-
Body mass index
- CACS:
-
Coronary artery calcium score
- CAD:
-
Coronary artery disease
- CI:
-
Confidence interval
- CRP:
-
C-reactive protein
- CCTA:
-
Coronary computed tomography angiography
- DBS:
-
Dried blood spot
- DHA:
-
Docosahexaenoic acid
- EDTA:
-
Ethylenediaminetetraacetic acid
- EPA:
-
Eicosapentaenoic acid
- FAME:
-
Fatty acid methyl esters
- LDL:
-
Low density lipoprotein
- PUFA:
-
Polyunsaturated fatty acids
- REDUCE-IT:
-
Reduction of cardiovascular events with icosapent ethyl-intervention trial
- SD:
-
Standard deviations
- SMuRFs:
-
Standard modifiable risk factors
- SPS:
-
Soft plaque score
- STEMI:
-
ST-elevation myocardial infarction
- STRENGTH:
-
Statin residual risk reduction with epanova in high cardiovascular risk patients with hypertriglyceridemia
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Acknowledgements
We would like to express our sincere gratitude to all individuals and institutions, particularly the study participants, University of Sydney Charles Perkins Centre, and the South Australian Medical and Research Institute (SAHMRI) whose invaluable contributions and support have made this research possible. We are additionally appreciative for the assistance of the radiographers and nursing staff from North Shore Radiology and Nuclear Medicine in St. Leonards, Australia. We would like to thank Zara Ali, Alexander Bate, Meghan Finemore, Jessica Hu, Tung Nguyen, and Luisa Osorio for their current and historic operational support of the BioHEART study and recruitment of participants included in this analysis.
Funding
The authors are grateful for the following financial support for the research, authorship, and publication of this article. PC is supported by an Australian Government Research Training Program (RTP) Postgraduate Research Scholarship; PJP is supported by a Level 3 Future Leader Fellowship from the National Heart Foundation of Australia (ID106656). GAF is supported by grants from the National Health and Medical Research Council (Australia), Heart Research Australia, and the NSW Office of Health and Medical Research.
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P.C., O.T., P.P., G.F. conceived and designed the study. O.T., B.D., R.G. acquired the data. P.C., D.Z. conducted the statistical analysis. P.C., D.Z., M.G., S.V., K.K., S.G., P.P., G.F., interpreted the data. All authors reviewed the manuscript and provided final approval for submission.
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Chhay, P., Zhu, D., Tang, O. et al. Plasma fatty acid profiles and coronary artery disease burden assessed by coronary CT angiography: an observational study. Sci Rep (2026). https://doi.org/10.1038/s41598-026-36845-z
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DOI: https://doi.org/10.1038/s41598-026-36845-z